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结肠扩张并发急性重症溃疡性结肠炎，通过加速英夫利昔单抗给药成功治疗

Colonic Dilatation Complicating Acute Severe Ulcerative Colitis Managed Successfully with Accelerated Infliximab Dosing.

作者信息

Bui Hoang Huu, Dang Luan Minh, Thi-Ngoc Vo Diem, Nguyen Chuong Dinh

机构信息

Department of Gastroenterology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Department of Internal Medicine, University Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

出版信息

Case Rep Gastroenterol. 2023 Feb 7;17(1):82-88. doi: 10.1159/000529152. eCollection 2023 Jan-Dec.

DOI:10.1159/000529152
PMID:36760465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9906040/
Abstract

Lately, emerging data suggest an association between the development of inflammatory bowel disease and anti-interleukin-17 therapy. Megacolon is a life-threatening complication of acute severe ulcerative colitis (ASUC), but its treatment has not yet been established in current practice guidelines. We report a rare case of known psoriasis treated by secukinumab in a patient who presented with ASUC and colonic dilatation. Neither steroids nor standard infliximab regimen was effective. Finally, rescue therapy with accelerated infliximab strategy resulted in excellent recovery. In certain cases of steroid-refractory ASUC complicated by megacolon, accelerated infliximab regimen can be an alternative to surgery.

摘要

最近，新出现的数据表明炎症性肠病的发展与抗白细胞介素-17治疗之间存在关联。巨结肠是急性重症溃疡性结肠炎（ASUC）的一种危及生命的并发症，但目前的实践指南中尚未确立其治疗方法。我们报告了一例罕见病例，一名已知患有银屑病的患者因ASUC和结肠扩张接受司库奇尤单抗治疗。类固醇和标准英夫利昔单抗方案均无效。最后，采用加速英夫利昔单抗策略进行抢救治疗，患者恢复良好。在某些合并巨结肠的类固醇难治性ASUC病例中，加速英夫利昔单抗方案可作为手术的替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/3b5d942514b8/crg-2022-0017-0001-529152_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/0fdcf76f4361/crg-2022-0017-0001-529152_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/b2df92b84ac1/crg-2022-0017-0001-529152_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/b5de907315e0/crg-2022-0017-0001-529152_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/3b5d942514b8/crg-2022-0017-0001-529152_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/0fdcf76f4361/crg-2022-0017-0001-529152_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/b2df92b84ac1/crg-2022-0017-0001-529152_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/b5de907315e0/crg-2022-0017-0001-529152_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162d/9906040/3b5d942514b8/crg-2022-0017-0001-529152_f4.jpg

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本文引用的文献

1
Gastroenterological safety of IL-17 inhibitors: a systematic literature review.IL-17 抑制剂的胃肠安全性：系统文献回顾。
Expert Opin Drug Saf. 2022 Feb;21(2):223-239. doi: 10.1080/14740338.2021.1960981. Epub 2021 Aug 6.
2
Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level: A case report.基于英夫利昔单抗谷浓度的加速英夫利昔单抗方案治疗急性重度溃疡性结肠炎：一例报告
World J Clin Cases. 2021 May 6;9(13):3219-3226. doi: 10.12998/wjcc.v9.i13.3219.
3
Paradoxical gastrointestinal effects of interleukin-17 blockers.
白介素-17 阻滞剂的矛盾性胃肠道作用。
Ann Rheum Dis. 2020 Sep;79(9):1132-1138. doi: 10.1136/annrheumdis-2020-217927. Epub 2020 Jul 21.
4
AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis.美国胃肠病学会关于中重度溃疡性结肠炎管理的临床实践指南。
Gastroenterology. 2020 Apr;158(5):1450-1461. doi: 10.1053/j.gastro.2020.01.006. Epub 2020 Jan 13.
5
Severe colitis complicating secukinumab (Cosentyx ) therapy.司库奇尤单抗（可善挺）治疗引发的严重结肠炎。
Clin Exp Dermatol. 2020 Apr;45(3):344-345. doi: 10.1111/ced.14149. Epub 2019 Dec 19.
6
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.英国胃肠病学会成人炎症性肠病管理共识指南。
Gut. 2019 Dec;68(Suppl 3):s1-s106. doi: 10.1136/gutjnl-2019-318484. Epub 2019 Sep 27.
7
A case of new onset ulcerative colitis following secukinumab treatment.司库奇尤单抗治疗后新发溃疡性结肠炎一例。
Br J Hosp Med (Lond). 2019 Sep 2;80(9):544-545. doi: 10.12968/hmed.2019.80.9.544.
8
A Rare Case of New-Onset Ulcerative Colitis following Initiation of Secukinumab.司库奇尤单抗治疗后新发溃疡性结肠炎1例罕见病例
Case Rep Med. 2019 Jul 31;2019:2975631. doi: 10.1155/2019/2975631. eCollection 2019.
9
ACG Clinical Guideline: Ulcerative Colitis in Adults.ACG 临床指南：成人溃疡性结肠炎。
Am J Gastroenterol. 2019 Mar;114(3):384-413. doi: 10.14309/ajg.0000000000000152.
10
Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: a retrospective analysis of pooled data from 21 clinical trials.接受司库奇尤单抗治疗的银屑病、银屑病关节炎和强直性脊柱炎患者中炎症性肠病的发生率：21 项临床试验汇总数据的回顾性分析。
Ann Rheum Dis. 2019 Apr;78(4):473-479. doi: 10.1136/annrheumdis-2018-214273. Epub 2019 Jan 23.