• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2 型糖尿病患者的动态功能结构改变。

Altered dynamic functional architecture in type 2 diabetes mellitus.

机构信息

First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

出版信息

Front Endocrinol (Lausanne). 2023 Jan 24;13:1117735. doi: 10.3389/fendo.2022.1117735. eCollection 2022.

DOI:10.3389/fendo.2022.1117735
PMID:36760808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9903314/
Abstract

INTRODUCTION

Type 2 diabetes mellitus (T2DM) can accelerate cognitive decline and even dementia so that the underlying mechanism deserves further exploration. In the resting state, brain function is still changing dynamically. At present, it is still unknown whether the dynamic functional connectivity (dFC) between various brain regions is in a stable state. It is necessary to interpret brain changes from a new perspective, that is, the stability of brain architecture.

METHODS

In this study, we used a fixed dynamic time scale to explore the stability of dynamic functional architecture in T2DM, then the dynamic effective connectivity (dEC) was used to further explain how information flows through dynamically fluctuating brain architecture in T2DM.

RESULT

Two brain regions with decreased stability were found including the right supra-marginal gyrus (SMG) and the right median cingulate gyrus (MCG) in T2DM subjects. The dEC variation has increased between the left inferior frontal gyrus (IFG) and the right MCG. The direction of causal flow is from the right MCG to the left IFG.

CONCLUSION

The combination of stability and dEC can not only show the stability of dynamic functional architecture in brain but also reflect the fluidity of brain information, which is an innovative and interesting attempt in the field of neuroimaging. The changes of dynamic architecture in T2DM patients may present an innovative perspective and explanation for their cognitive decline.

摘要

简介

2 型糖尿病（T2DM）可加速认知能力下降甚至痴呆，因此其潜在机制值得进一步探索。在静息状态下，大脑功能仍在动态变化。目前尚不清楚各脑区之间的动态功能连接（dFC）是否处于稳定状态。有必要从一个新的角度，即大脑结构的稳定性，来解释大脑的变化。

方法

本研究使用固定的动态时间尺度来探索 T2DM 患者中动态功能结构的稳定性，然后使用动态有效连接（dEC）来进一步解释信息如何在 T2DM 中动态波动的大脑结构中流动。

结果

在 T2DM 患者中发现了两个稳定性降低的脑区，包括右侧缘上回（SMG）和右侧中央扣带回（MCG）。左侧额下回（IFG）和右侧 MCG 之间的 dEC 变化增加。因果流的方向是从右侧 MCG 到左侧 IFG。

结论

稳定性和 dEC 的结合不仅可以显示大脑中动态功能结构的稳定性，还可以反映大脑信息的流动性，这是神经影像学领域的一项创新和有趣的尝试。T2DM 患者的动态结构变化可能为其认知能力下降提供了一个创新的视角和解释。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/db94166a3e5a/fendo-13-1117735-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/0d1a5582ec89/fendo-13-1117735-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/387cc228e8ac/fendo-13-1117735-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/86578d023b74/fendo-13-1117735-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/8b53fe5dd48f/fendo-13-1117735-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/db94166a3e5a/fendo-13-1117735-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/0d1a5582ec89/fendo-13-1117735-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/387cc228e8ac/fendo-13-1117735-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/86578d023b74/fendo-13-1117735-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/8b53fe5dd48f/fendo-13-1117735-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b48b/9903314/db94166a3e5a/fendo-13-1117735-g005.jpg

相似文献

1
Altered dynamic functional architecture in type 2 diabetes mellitus.2 型糖尿病患者的动态功能结构改变。
Front Endocrinol (Lausanne). 2023 Jan 24;13:1117735. doi: 10.3389/fendo.2022.1117735. eCollection 2022.
2
Altered functional connectivity of brain regions based on a meta-analysis in patients with T2DM: A resting-state fMRI study.基于 T2DM 患者的元分析的脑区功能连接改变：静息态 fMRI 研究。
Brain Behav. 2020 Aug;10(8):e01725. doi: 10.1002/brb3.1725. Epub 2020 Jun 18.
3
Abnormal functional connectivity in the right dorsal anterior insula associated with cognitive dysfunction in patients with type 2 diabetes mellitus.右侧背侧前脑岛异常功能连接与 2 型糖尿病患者认知功能障碍有关。
Brain Behav. 2022 Jun;12(6):e2553. doi: 10.1002/brb3.2553. Epub 2022 May 11.
4
Aberrant Brain Functional Connectivity Strength and Effective Connectivity in Patients with Type 2 Diabetes Mellitus.2 型糖尿病患者脑功能连接强度和有效连接的改变。
J Diabetes Res. 2021 Nov 28;2021:5171618. doi: 10.1155/2021/5171618. eCollection 2021.
5
Interhemispheric resting-state functional connectivity abnormalities in type 2 diabetes patients.2 型糖尿病患者大脑两半球静息状态功能连接异常。
Ann Palliat Med. 2021 Jul;10(7):8123-8133. doi: 10.21037/apm-21-1655.
6
Static and dynamic functional connectivity differences between migraine and persistent post-traumatic headache: A resting-state magnetic resonance imaging study.静息态功能磁共振成像研究偏头痛和持续性创伤后头痛的静息态和动态功能连接差异。
Cephalalgia. 2019 Oct;39(11):1366-1381. doi: 10.1177/0333102419847728. Epub 2019 May 1.
7
Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment.2 型糖尿病伴和不伴轻度认知障碍患者的局部一致性和功能脑网络改变。
Sci Rep. 2020 Dec 4;10(1):21254. doi: 10.1038/s41598-020-76495-3.
8
Altered functional connectivity of the posterior cingulate cortex in type 2 diabetes with cognitive impairment.2 型糖尿病伴认知障碍患者后扣带回皮质功能连接改变。
Brain Imaging Behav. 2019 Dec;13(6):1699-1707. doi: 10.1007/s11682-018-0017-8.
9
Aberrant Functional Connectivity of the Posterior Cingulate Cortex in Type 2 Diabetes Without Cognitive Impairment and Microvascular Complications.2 型糖尿病无认知障碍和微血管并发症患者后扣带回皮质的功能连接异常。
Front Endocrinol (Lausanne). 2021 Oct 25;12:722861. doi: 10.3389/fendo.2021.722861. eCollection 2021.
10
Glucose Fluctuations Are Linked to Disrupted Brain Functional Architecture and Cognitive Impairment.葡萄糖波动与大脑功能结构紊乱和认知障碍有关。
J Alzheimers Dis. 2020;74(2):603-613. doi: 10.3233/JAD-191217.

引用本文的文献

1
Resting-state neural activity and cerebral blood flow alterations in type 2 diabetes mellitus: Insights from hippocampal subfields.2 型糖尿病中海马亚区静息态神经活动和脑血流的改变：来自海马亚区的见解。
Brain Behav. 2024 Jul;14(7):e3600. doi: 10.1002/brb3.3600.

本文引用的文献

1
The cumulative therapeutic effect of acupuncture in patients with migraine without aura: Evidence from dynamic alterations of intrinsic brain activity and effective connectivity.针刺治疗无先兆偏头痛患者的累积疗效：来自脑内固有活动和有效连接动态变化的证据
Front Neurosci. 2022 Jul 19;16:925698. doi: 10.3389/fnins.2022.925698. eCollection 2022.
2
Aberrant Brain Spontaneous Activity and Synchronization in Type 2 Diabetes Mellitus Subjects Without Mild Cognitive Impairment.无轻度认知障碍的2型糖尿病患者的异常脑自发活动与同步性
Front Neurosci. 2021 Dec 16;15:749730. doi: 10.3389/fnins.2021.749730. eCollection 2021.
3
A scoping review of resting-state brain functional alterations in Type 2 diabetes.
2 型糖尿病静息态脑功能改变的范围性综述。
Front Neuroendocrinol. 2022 Apr;65:100970. doi: 10.1016/j.yfrne.2021.100970. Epub 2021 Dec 16.
4
Altered Hippocampal Subfields Volumes Is Associated With Memory Function in Type 2 Diabetes Mellitus.海马亚区体积改变与2型糖尿病的记忆功能相关。
Front Neurol. 2021 Nov 25;12:756500. doi: 10.3389/fneur.2021.756500. eCollection 2021.
5
A Tale of Two Diseases: Exploring Mechanisms Linking Diabetes Mellitus with Alzheimer's Disease.两种疾病的故事：探索将糖尿病与阿尔茨海默病联系起来的机制
J Alzheimers Dis. 2022;85(2):485-501. doi: 10.3233/JAD-210612.
6
Abnormal Stability of Dynamic Functional Architecture in Amyotrophic Lateral Sclerosis: A Preliminary Resting-State fMRI Study.肌萎缩侧索硬化症中动态功能结构的异常稳定性：一项初步静息态功能磁共振成像研究
Front Neurol. 2021 Oct 13;12:744688. doi: 10.3389/fneur.2021.744688. eCollection 2021.
7
Impact of Glycated Hemoglobin (HbA1c) on cognitive functions in Type 2 diabetic patients.糖化血红蛋白 (HbA1c) 对 2 型糖尿病患者认知功能的影响。
Eur Rev Med Pharmacol Sci. 2021 Oct;25(19):5978-5985. doi: 10.26355/eurrev_202110_26875.
8
Altered Gray Matter Volume, Functional Connectivity, and Degree Centrality in Early-Onset Type 2 Diabetes Mellitus.早发型2型糖尿病患者脑灰质体积、功能连接性及中心性的改变
Front Neurol. 2021 Sep 9;12:697349. doi: 10.3389/fneur.2021.697349. eCollection 2021.
9
Cognitive function among older adults with diabetes and prediabetes, NHANES 2011-2014.糖尿病和糖尿病前期老年患者的认知功能，NHANES 2011-2014。
Diabetes Res Clin Pract. 2021 Aug;178:108939. doi: 10.1016/j.diabres.2021.108939. Epub 2021 Jul 3.
10
Disturbed Interhemispheric Functional and Structural Connectivity in Type 2 Diabetes.2 型糖尿病患者大脑两半球间功能和结构连接的紊乱。
J Magn Reson Imaging. 2022 Feb;55(2):424-434. doi: 10.1002/jmri.27813. Epub 2021 Jun 28.