Muntyanu Anastasiya, Martinez-Cabriales Sylvia A, Yeung Jensen
Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Division of Clinical Sciences, Department of Medicine, Northern Ontario School of Medicine, Sudbury, ON, Canada.
SAGE Open Med Case Rep. 2023 Feb 6;11:2050313X231152054. doi: 10.1177/2050313X231152054. eCollection 2023.
Psoriasis is a common cutaneous disease, and often these patients require treatment with biologics. Screening for latent tuberculosis is an important step in the pre-biologic work-up. A 58-year-old woman with moderate-to-severe psoriasis was found to be positive for latent tuberculosis during pre-biologic screening. She received rifampicin for 6 months and had complete resolution of her psoriasis, with persistent remission at 1-year follow-up. Improvement could be attributed to the immunomodulatory effects of rifampicin. Another theory proposes the existence of a tuberculosis-related type of psoriasis that improves when tuberculosis is adequately treated.
银屑病是一种常见的皮肤病，这些患者通常需要使用生物制剂进行治疗。在使用生物制剂前的检查中，筛查潜伏性结核是重要的一步。一名58岁的中度至重度银屑病女性患者在使用生物制剂前的筛查中被发现潜伏性结核呈阳性。她接受了6个月的利福平治疗，银屑病完全消退，在1年的随访中持续缓解。病情改善可能归因于利福平的免疫调节作用。另一种理论认为存在一种与结核相关的银屑病类型，当结核得到充分治疗时病情会改善。
