Ruiz Esparza Garrido Ruth, Gutiérrez Mercedes, Ángel Velázquez Flores Miguel
Investigadora por México, Non-coding RNAs Laboratory, Medical Research Unit in Human Genetics, Children's Hospital 'Dr. Silvestre Frenk Freund', National Medical Center XXI Century, Mexican Institute of Social (Instituto Mexicano del Seguro Social, IMSS), Doctores, Mexico City 06720, Mexico.
ATSO PHARMA Laboratory, Jardines del Pedregal, Álvaro Obregón, Mexico City 01900, Mexico.
Mol Clin Oncol. 2023 Jan 18;18(2):13. doi: 10.3892/mco.2023.2609. eCollection 2023 Feb.
Cervical cancer (CC) is a public health problem worldwide, including Mexico. This type of cancer is the fourth most frequent in women worldwide; in Mexico it is the second most common type in women after breast cancer. The diagnosis of CC is based mainly on Pap smears and colposcopy and the identification of molecular tools that serve as a support for these methods is urgent. Regarding this, differential expressions of specific circulating biomolecules has been detected and, based on this, they have been postulated as potential biomarkers for CC diagnosis, prognosis, and/or to identify the response to treatments. Importantly, the combined analysis of these molecules considerably improves their efficacy as biomarkers and their potential use in the medical attention is promising.
宫颈癌（CC）是包括墨西哥在内的全球公共卫生问题。这种癌症是全球女性中第四大常见癌症；在墨西哥，它是仅次于乳腺癌的第二大常见女性癌症类型。宫颈癌的诊断主要基于巴氏涂片和阴道镜检查，迫切需要确定作为这些方法辅助手段的分子工具。关于这一点，已经检测到特定循环生物分子的差异表达，并据此将它们假定为宫颈癌诊断、预后和/或确定治疗反应的潜在生物标志物。重要的是，对这些分子的联合分析大大提高了它们作为生物标志物的功效，并且它们在医疗中的潜在用途很有前景。
