Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, Third Xiangya Hospital, Central South University, Changsha, China.
Front Immunol. 2023 Jan 24;14:1066222. doi: 10.3389/fimmu.2023.1066222. eCollection 2023.
Ischemia-reperfusion injury (IRI) is a common complication of surgery, which can cause rapid deterioration of the liver function, increase the risk of graft rejection, and seriously affect the prognosis of patients. The signal transducer and activator of transcription 3 (STAT3) protein has been implicated in pathogenesis of IRI. STAT3 influences the mitochondria through multiple pathways and is also involved in apoptosis and other forms of programmed cell death. STAT3 is associated with Janus kinase (JAK), phosphoinositide-3 kinase (PI3K), and heme oxygenase-1 (HO-1) in liver IRI. The STAT3 pathway plays a dual role in IRI as it can also regulate lipid metabolism which may have potential for treating IRI fatty liver. In this review, we summarize research on the function of STAT3 in liver IRI to provide references for its application in the clinic.
缺血再灌注损伤（IRI）是手术的常见并发症，可导致肝功能迅速恶化，增加移植物排斥的风险，并严重影响患者的预后。信号转导子和转录激活子 3（STAT3）蛋白与 IRI 的发病机制有关。STAT3 通过多种途径影响线粒体，并参与细胞凋亡和其他形式的程序性细胞死亡。STAT3 与肝 IRI 中的 Janus 激酶（JAK）、磷酸肌醇 3 激酶（PI3K）和血红素加氧酶 1（HO-1）有关。STAT3 通路在 IRI 中具有双重作用，因为它还可以调节脂质代谢，这可能为治疗 IRI 脂肪肝提供潜力。在这篇综述中，我们总结了 STAT3 在肝 IRI 中的功能研究，为其在临床中的应用提供参考。
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