School of Chemical Engineering, Sungkyunkwan University, Suwon 16149, Republic of Korea.
Interdisciplinary Program in Biocosmetics, Sungkyunkwan University, Suwon 16419, Republic of Korea.
J Mater Chem B. 2023 Mar 8;11(10):2135-2144. doi: 10.1039/d2tb02734h.
This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone -acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
本研究介绍了一种多层神经酰胺核心结构的微载体平台，可实现实质性的皮肤屏障功能恢复。我们的方法主要集中在通过固化细菌纤维素纳米纤维（BCNF）包裹的富含神经酰胺的脂质微球（CerMPs）来制备。油滴由神经酰胺 NP（植物鞘氨醇骨架与饱和硬脂酸酰化）和脂肪酸（FAs）组成，其比例是指定的。薄的 BCNF 壳层长时间完全阻止了 CerMPs 中神经酰胺分子晶体的生长。CerMP 核呈现出多层结构，其中层间距离和横向堆积可以使用具有不同烷基链长的 FAs 来操纵。CerMPs 显著降低了经皮水分流失，同时恢复了受损皮肤表皮的结构完整性。本文的研究结果表明，CerMP 体系为开发各种类型的亲肤制剂提供了一种实用的方法，可增强皮肤屏障功能。
