Chen Jie, Liu Changjie, Yang Yuan, Gong Xue, Qian Huan
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Xuhui, District, China.
SIMPLY THIS Skin Ecology Research Institute, Shili (Shanghai) Biotechology Co., Ltd, Shanghai, China.
Tissue Barriers. 2024 May 31:2361197. doi: 10.1080/21688370.2024.2361197.
The skin is the largest organ of the human body and is widely considered to be the first-line defense of the body, providing essential protection against mechanical, physical, and chemical damage. Keratinocytes are the primary cells of the outer layer of the epidermis, which acts as a mechanical and permeability barrier. The epidermis is a permanently renewed tissue where undifferentiated keratinocytes located at the basal layer proliferate and migrate to the overlying layers. Here we report that some components of keratinocytes affect the formation and differentiation of the stratum corneum, which is the most specialized layer of the epidermis.
皮肤是人体最大的器官，被广泛认为是身体的第一道防线，为机体提供针对机械、物理和化学损伤的重要保护。角质形成细胞是表皮外层的主要细胞，表皮起着机械性和通透性屏障的作用。表皮是一个不断更新的组织，位于基底层的未分化角质形成细胞在此增殖并迁移至上层。在此，我们报道角质形成细胞的某些成分会影响角质层的形成和分化，角质层是表皮最特殊的一层。
