脓毒症期间糖萼改变的潜在营养和药物治疗

Potential nutritional and pharmacological treatment of glycocalyx alterations during sepsis.

作者信息

Pergolizzi Carola, Franchi Federico, Taccone Fabio S, Preiser Jean-Charles, Scolletta Sabino

机构信息

Anesthesia and Intensive Care Unit, University Hospital of Siena, University of Siena, Siena, Italy.

Department of Intensive Care, Cliniques Universitaires de Bruxelles - Hôpital Erasme, University of Brussels, Brussels, Belgium.

出版信息

Minerva Anestesiol. 2023 Apr;89(4):341-350. doi: 10.23736/S0375-9393.22.16834-3. Epub 2023 Feb 10.

DOI:10.23736/S0375-9393.22.16834-3

PMID:36762983

Abstract

During sepsis, a combination of pathophysiological insults disrupts the glycocalyx. The thickness of the glycocalyx is correlated with parameters of disease severity, making it a potential new and independent target for therapeutic strategies in sepsis. The aim of this review was to examine potential beneficial effects of nutritional and pharmacological measures on glycocalyx alterations during sepsis and their timing.

摘要

在脓毒症期间，多种病理生理损伤会破坏糖萼。糖萼的厚度与疾病严重程度参数相关，这使其成为脓毒症治疗策略中一个潜在的新的独立靶点。本综述的目的是研究营养和药理学措施对脓毒症期间糖萼改变的潜在有益作用及其时机。