Department of Physics, The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Parks Road, Oxford OX1 3PU, United Kingdom.
Phys Rev Lett. 2023 Jan 20;130(3):038202. doi: 10.1103/PhysRevLett.130.038202.
We use a computational phase-field model together with analytical analysis to study how intercellular active forces can mediate individual cell morphology and collective motion in a confluent cell monolayer. We explore the regime where intercellular forces dominate the tissue dynamics, and polar forces are negligible. Contractile intercellular interactions lead to cell elongation, nematic ordering, and active turbulence characterized by motile topological defects. Extensile interactions result in frustration, and perpendicular cell orientations become more prevalent. Furthermore, we show that contractile behavior can change to extensile behavior if anisotropic fluctuations in cell shape are considered.
我们使用计算相场模型结合解析分析来研究细胞间的主动力如何调节细胞单层的个体细胞形态和集体运动。我们研究了细胞间力主导组织动力学的状态，忽略了极向力。收缩性细胞间相互作用导致细胞伸长、向列有序和以运动拓扑缺陷为特征的主动湍流。伸展性相互作用导致挫折，垂直的细胞方向变得更加普遍。此外，如果考虑细胞形状的各向异性波动，我们还表明收缩行为可以改变为伸展行为。
