纤维蛋白原样蛋白 2 在炎症性疾病中的作用：一个未来的治疗靶点。
Fibrinogen-like protein 2 in inflammatory diseases: A future therapeutic target.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, China.
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, China.
出版信息
Int Immunopharmacol. 2023 Mar;116:109799. doi: 10.1016/j.intimp.2023.109799. Epub 2023 Feb 8.
Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen family, exists as a membrane-bound protein with immune-associated coagulation activity and a soluble form possessing immunosuppressive functions. The immunomodulatory role of FGL2 is evident in fibrin deposition-associated inflammatory diseases and cancer, suggesting that FGL2 expression could be exploited as a disease biomarker and a therapeutic target. Recently, in vitro studies and knockout and transgenic animal FGL2 models have been used by us and others to reveal the involvement of FGL2 in the pathogenesis of various inflammatory diseases. This review summarizes our current knowledge of the immunomodulatory role of FGL2 in inflammatory diseases and examines the role of FGL2 as a potential therapeutic target.
纤维蛋白原样蛋白 2（FGL2）是纤维蛋白家族的一员，以具有免疫相关凝血活性的膜结合蛋白和具有免疫抑制功能的可溶性形式存在。FGL2 在与纤维蛋白沉积相关的炎症性疾病和癌症中的免疫调节作用表明，FGL2 的表达可以作为疾病生物标志物和治疗靶点加以利用。最近，我们和其他人使用体外研究以及敲除和转基因动物 FGL2 模型来揭示 FGL2 参与各种炎症性疾病发病机制的情况。本综述总结了我们目前对 FGL2 在炎症性疾病中的免疫调节作用的认识，并探讨了 FGL2 作为潜在治疗靶点的作用。
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