Huang Yi, Xiao Xue, Sadeghi Fatemeh, Feychting Maria, Hammar Niklas, Fang Fang, Zhang Zhe, Liu Qianwei
Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumor (Guangxi Medical University), Ministry of Education, Guangxi Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Nanning, China.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Cancer Lett. 2023 Mar 31;557:216091. doi: 10.1016/j.canlet.2023.216091. Epub 2023 Feb 8.
Multiple studies have investigated the role of carbohydrate and lipid metabolism on the risk of head and neck cancer (HNC), with however conflicting results. We performed a study of 561,388 individuals of the Swedish AMORIS Cohort with blood test results on nine biomarkers for carbohydrate, lipid, and apolipoprotein metabolism during 1985-1996. We examined the associations of these biomarkers with the future risk of HNC through 2020 and demonstrated the temporal changes of these biomarkers during the decades before cancer diagnosis. We found that there was a positive association between blood level of glucose, total cholesterol (TC), triglycerides (TG), and Apoprotein A-I (ApoA-I) and the risk of HNC. Per standard deviation increase, the hazard ratio (HR) was 1.05 (95% confidence interval [CI] 1.02-1.09) for glucose, 1.09 (95% CI 1.05-1.13) for TC, 1.13 (95% CI 1.08-1.17) for TG, and 1.11 (95% CI 1.04-1.19) for ApoA-I. The associations were primarily noted for squamous cell carcinoma but not adenocarcinoma. Compared to controls, patients with HNC, primarily squamous cell carcinoma, showed constantly higher levels of glucose, TC, TG, and ApoA-I during the 30 years before diagnosis. In conclusion, findings of the study add new and high-quality evidence to the early involvement of carbohydrate and lipid metabolism in the oncogenesis of human cancer.
多项研究调查了碳水化合物和脂质代谢在头颈癌（HNC）风险中的作用，但结果相互矛盾。我们对瑞典AMORIS队列中的561388名个体进行了一项研究，这些个体在1985年至1996年期间有关于碳水化合物、脂质和载脂蛋白代谢的9种生物标志物的血液检测结果。我们通过2020年研究了这些生物标志物与HNC未来风险的关联，并展示了在癌症诊断前几十年中这些生物标志物的时间变化。我们发现血糖、总胆固醇（TC）、甘油三酯（TG）和载脂蛋白A-I（ApoA-I）的血液水平与HNC风险呈正相关。每增加一个标准差，葡萄糖的风险比（HR）为1.05（95%置信区间[CI]1.02 - 1.09），TC为1.09（95%CI 1.05 - 1.13），TG为1.13（95%CI 1.08 - 1.17），ApoA-I为1.11（95%CI 1.04 - 1.19）。这些关联主要见于鳞状细胞癌，而非腺癌。与对照组相比，HNC患者（主要是鳞状细胞癌）在诊断前30年期间血糖、TC、TG和ApoA-I水平持续较高。总之，该研究结果为碳水化合物和脂质代谢在人类癌症发生过程中的早期参与提供了新的高质量证据。
