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[血流动力学紊乱对大鼠在体肝脏跨上皮电位的影响]

[Effect of hemodynamic disorders on the transepithelial potential of the rat liver in vivo].

作者信息

Sarbash V I, Rymarchuk V I, Malenkov A G, Radkevich L A

出版信息

Biull Eksp Biol Med. 1987 Oct;104(10):444-5.

PMID:3676465
Abstract

The presence of transepithelial electrical potential (TEP) formed on the border between the interstitium and the interior of the rat liver bile capillary has been demonstrated. The initial TEP value (II+ 3 mV) reduced rapidly to zero after the ligation of different portal fissure vessels, while ischemia arrest led to TEP restoration. True periodical oscillations of TEP value with the period and amplitude of about 30 s and 1-2 mV, respectively, were registered. These oscillations appeared in all cases of liver ischemia 5-7 min after ischemia removal and lingered till the end of the experiment. It was assumed that variations in TEP and membrane potential of hepatocytes have the common nature.

摘要

已证实在大鼠肝脏胆小管间质与内部之间的边界上形成了跨上皮电势(TEP)。在结扎不同的门静脉裂隙血管后,初始TEP值(II + 3 mV)迅速降至零,而缺血停止导致TEP恢复。记录到TEP值的真正周期性振荡,其周期和幅度分别约为30秒和1 - 2 mV。这些振荡出现在所有肝脏缺血病例中,在缺血消除后5 - 7分钟出现,并持续到实验结束。据推测,TEP的变化与肝细胞的膜电位具有共同的性质。

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