Nepomniashchikh L M, Lushnikova E L, Nepomniashchikh G I, Chernokalova M G, Postnikova O A
Biull Eksp Biol Med. 1987 Nov;104(11):625-30.
A stereologic study of the myocardium exposure to cold for 4 hours, 8 and 16 days was carried out on Wistar rats. It has been shown that during the first 8 days acute hemodynamic disorders and cardiomyocyte contractures developed. These changes were followed by a decrease in the volume and surface capillary density resulting in the impairment of transcapillary exchange and reduction of the intracellular regeneration processes in cardiomyocytes. By the 16th day the compensatory-adaptive reactions developed, i.e., the volume and surface density of endothelial cells and capillaries was increased. At the same time the lysis processes caused by the general decrease in the inflow of plastic substances to the myocardium due to the increase in thermogenesis were revealed in part of cardiomyocytes. These changes in parenchymatous cells were accompanied by the intensification of desmoplastic reactions in the myocardial stroma.
对Wistar大鼠进行了一项关于心肌暴露于寒冷环境4小时、8天和16天的体视学研究。结果表明，在最初的8天里出现了急性血流动力学紊乱和心肌细胞挛缩。这些变化之后是毛细血管容积和表面密度降低，导致毛细血管间交换受损以及心肌细胞内再生过程减少。到第16天，出现了代偿性适应反应，即内皮细胞和毛细血管的容积及表面密度增加。与此同时，在部分心肌细胞中发现了由于产热增加导致进入心肌的可塑性物质总体流入减少而引起的溶解过程。实质细胞的这些变化伴随着心肌间质中纤维组织形成反应的增强。
