Department of Cardiac Surgery, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fujian Medical University, Fuzhou, China.
BMC Pediatr. 2023 Feb 11;23(1):73. doi: 10.1186/s12887-023-03843-3.
To investigate health-related quality of life (HRQOL) in children with postoperative delirium (POD) after surgical repair of ventricular septal defects (VSDs).
A total of 109 patients were enrolled and assigned to the POD group (n = 47) and the non-POD group (n = 62). HRQOL was assessed by the PedsQLTM 3.0 Cardiac Module at discharge, and at the three- and six-month postoperative follow.
Significant differences were detected in age, operation time, CPB time, mechanical ventilation duration, and length of ICU stay between the two groups, whereas sex and the VSD size did not significantly differ between groups. In terms of "cardiac heart problems and treatment" and "treatment-II", the HRQOL scores of the non-POD group were significantly better than those of the POD group. In terms of "perceived physical appearance" and "treatment anxiety", the POD group had significantly higher scores than the non-POD group at discharge and at the three-month postoperative follow-up. In terms of "cognitive problems" and "communication", the occurrence of POD still affected HRQOL at three months postoperatively, but the effect was significantly reduced at six months postoperatively. In terms of "total scores", both groups scored increasingly higher over time. The non-POD group had higher scores at discharge and three months postoperatively than the POD group, but no significant difference persisted at six months postoperatively.
During the follow-up period, the HRQOL of the children with POD after surgical repair of VSD was inferior to that of the children without POD at discharge and three months postoperatively. However, the HRQOL did not differ between the two groups at six months postoperatively.
调查手术后谵妄（POD）对室间隔缺损（VSD）修补术后儿童健康相关生活质量（HRQOL）的影响。
共纳入 109 例患者，分为 POD 组（n=47）和非 POD 组（n=62）。出院时及术后 3 个月、6 个月采用 PedsQLTM 3.0 心脏模块评估 HRQOL。
两组在年龄、手术时间、CPB 时间、机械通气时间和 ICU 住院时间方面存在显著差异，而性别和 VSD 大小无显著差异。在“心脏问题及治疗”和“治疗-II”方面，非 POD 组 HRQOL 评分显著优于 POD 组。在“感知身体外观”和“治疗焦虑”方面，POD 组在出院时和术后 3 个月的 HRQOL 评分显著高于非 POD 组。在“认知问题”和“沟通”方面，POD 的发生仍会影响术后 3 个月的 HRQOL，但术后 6 个月的影响显著降低。在“总分”方面，两组的得分随时间逐渐升高。非 POD 组在出院时和术后 3 个月的得分高于 POD 组，但术后 6 个月时无显著差异。
在随访期间，VSD 修补术后发生 POD 的儿童的 HRQOL 在出院时和术后 3 个月时劣于未发生 POD 的儿童，但在术后 6 个月时两组之间无差异。
