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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Clin Exp Pharmacol Physiol. 1979 Jan-Feb;6(1):31-5. doi: 10.1111/j.1440-1681.1979.tb00004.x.

To evaluate the mechanism of action of imipramine in enuresis nocturna, we compared the effects of imipramine with those of scopolamine butylbromide in fourteen children suffering from this condition. A double-blind, cross-over design was used. 2. Imipramine, 10--20 mg, was superior to scopolamine butylbromide (10--20 mg), in eleven of the fourteen subjects (P less than 0.01), and the latter drug was no better than the placebo. 3. As scopolamine butylbromide does not cross the blood-brain barrier, it is concluded that peripheral antimuscarinic effects are not important in the beneficial effects of imipramine in enuresis nocturna. 4. The therapeutic effects of imipramine in depression frequently take 3 to 4 weeks to develop. Such a delay was not seen in our enuretic patients. Thus the mechanism of the drug in the two conditions is probably different.

为评估丙咪嗪治疗小儿夜尿症的作用机制，我们比较了丙咪嗪与丁溴东莨菪碱对14例患有此症儿童的疗效。采用双盲交叉设计。2. 14例受试者中，11例使用10 - 20毫克丙咪嗪的效果优于使用10 - 20毫克丁溴东莨菪碱（P小于0.01），且后一种药物并不比安慰剂效果好。3. 由于丁溴东莨菪碱不能透过血脑屏障，得出结论：外周抗毒蕈碱作用对丙咪嗪治疗小儿夜尿症的有益效果并不重要。4. 丙咪嗪治疗抑郁症的疗效通常需要3至4周才显现。而在我们的遗尿症患者中未见到这种延迟。因此该药物在这两种病症中的作用机制可能不同。

Clin Exp Pharmacol Physiol. 1979 Jan-Feb;6(1):31-5. doi: 10.1111/j.1440-1681.1979.tb00004.x.

To evaluate the mechanism of action of imipramine in enuresis nocturna, we compared the effects of imipramine with those of scopolamine butylbromide in fourteen children suffering from this condition. A double-blind, cross-over design was used. 2. Imipramine, 10--20 mg, was superior to scopolamine butylbromide (10--20 mg), in eleven of the fourteen subjects (P less than 0.01), and the latter drug was no better than the placebo. 3. As scopolamine butylbromide does not cross the blood-brain barrier, it is concluded that peripheral antimuscarinic effects are not important in the beneficial effects of imipramine in enuresis nocturna. 4. The therapeutic effects of imipramine in depression frequently take 3 to 4 weeks to develop. Such a delay was not seen in our enuretic patients. Thus the mechanism of the drug in the two conditions is probably different.

为评估丙咪嗪治疗小儿夜尿症的作用机制，我们比较了丙咪嗪与丁溴东莨菪碱对14例患有此症儿童的疗效。采用双盲交叉设计。2. 14例受试者中，11例使用10 - 20毫克丙咪嗪的效果优于使用10 - 20毫克丁溴东莨菪碱（P小于0.01），且后一种药物并不比安慰剂效果好。3. 由于丁溴东莨菪碱不能透过血脑屏障，得出结论：外周抗毒蕈碱作用对丙咪嗪治疗小儿夜尿症的有益效果并不重要。4. 丙咪嗪治疗抑郁症的疗效通常需要3至4周才显现。而在我们的遗尿症患者中未见到这种延迟。因此该药物在这两种病症中的作用机制可能不同。