接受肝细胞癌监测的慢性肝病患者因早期诊断和高切除率而对胰腺癌有良好的长期预后。

Patients with Chronic Liver Disease under Surveillance for Hepatocellular Carcinoma Have a Favorable Long-Term Outcome for Pancreatic Cancer Due to Early Diagnosis and High Resection Rate.

作者信息

Kumagi Teru, Terao Takashi, Kuroda Taira, Koizumi Mitsuhito, Imamura Yoshiki, Ohno Yoshinori, Yokota Tomoyuki, Azemoto Nobuaki, Uesugi Kazuhiro, Kisaka Yoshiyasu, Tanaka Yoshinori, Shibata Naozumi, Miyata Hideki, Miyake Teruki, Hiasa Yoichi

机构信息

Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To-on 791-0295, Japan.

Postgraduate Medical Education Center, Ehime University Hospital, To-on 791-0295, Japan.

出版信息

Cancers (Basel). 2023 Jan 17;15(3):561. doi: 10.3390/cancers15030561.

DOI:10.3390/cancers15030561

PMID:36765521

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9913713/

Abstract

Patients with viral hepatitis-related chronic liver disease (CLD) under surveillance for hepatocellular carcinoma (HCC) are often diagnosed with pancreatic cancer (PC) at an early stage. However, the long-term outcomes of these patients are unclear. We aimed to clarify the long-term outcomes of patients with PC with viral hepatitis-related CLD using a chart review. Data collection included the Union for International Cancer Control (UICC) stage at PC diagnosis, hepatitis B virus and hepatitis C virus status, and long-term outcomes. The distribution of the entire cohort ( = 552) was as follows: early stage (UICC 0-IB; = 52, 9.5%) and non-early stages (UICC IIA-IV; = 500, 90.5%). At diagnosis, the HCC surveillance group ( = 18) had more patients in the early stages than the non-surveillance group ( = 534) (50% vs. 8.0%), leading to a higher indication rate for surgical resection (72.2% vs. 29.8%) and a longer median survival time (19.0 months vs. 9.9 months). We confirmed that patients with viral hepatitis-related CLD under HCC surveillance were diagnosed with PC at an early stage. Because of the higher indication rate for surgical resection in these patients, they had favorable long-term outcomes for PC.

摘要

接受肝细胞癌（HCC）监测的病毒性肝炎相关慢性肝病（CLD）患者，常被早期诊断为胰腺癌（PC）。然而，这些患者的长期预后尚不清楚。我们旨在通过图表回顾来阐明病毒性肝炎相关CLD合并PC患者的长期预后。数据收集包括PC诊断时的国际癌症控制联盟（UICC）分期、乙型肝炎病毒和丙型肝炎病毒状态以及长期预后。整个队列（n = 552）的分布如下：早期（UICC 0 - IB；n = 52，9.5%）和非早期（UICC IIA - IV；n = 500，90.5%）。诊断时，HCC监测组（n = 18）早期患者比非监测组（n = 534）更多（50%对8.0%），导致手术切除指征率更高（72.2%对29.8%），中位生存时间更长（19.0个月对9.9个月）。我们证实，接受HCC监测的病毒性肝炎相关CLD患者被早期诊断为PC。由于这些患者手术切除指征率较高，他们的PC长期预后良好。