Hong Rui, Yang Dianxu, Jing Yao, Chen Shiwen, Tian Hengli, Yang Yang
Department of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Cancers (Basel). 2023 Jan 31;15(3):883. doi: 10.3390/cancers15030883.
PIEZO1 is ubiquitously expressed in cells in different kinds of tissues throughout the body, which can sense physical or mechanical stimuli and translate them into intracellular electrochemical signals to regulate organism functions. In particular, PIEZO1 appears in complex interactive regulatory networks as a central node, governing normal and pathological functions in the body. However, the effect and mechanism of the activation or expression of PIEZO1 in diseases of the central nervous system (CNS) remain unclear. On one hand, in CNS diseases, pathophysiological processes in neurons and glial are often accompanied by variations in the mechanical properties of the cellular and extracellular matrix stiffness. The expression of PIEZO1 can therefore be upregulated, in responding to mechanical stimulation, to drive the biological process in cells, which in turns indirectly affects the cellular microenvironment, resulting in alterations of the cellular status. On the other hand, it may have contradictory effects with the change of active patterns and/or subcellular location. This review highlights the biological processes involved with PIEZO1 in CNS cells, with special emphasis on its multiple roles in glioma-associated phenotypes. In conclusion, PIEZO1 can be used as an indicator to assess the malignancy and prognosis of patients with gliomas, as well as a therapeutic target for clinical application following fully exploring the potential mechanism of PIEZO1 in CNS diseases.
Piezo1在全身不同组织的细胞中广泛表达，它能够感知物理或机械刺激，并将其转化为细胞内电化学信号以调节机体功能。特别是，Piezo1作为核心节点出现在复杂的交互调节网络中，调控着机体的正常和病理功能。然而，Piezo1的激活或表达在中枢神经系统（CNS）疾病中的作用及机制仍不清楚。一方面，在CNS疾病中，神经元和神经胶质细胞的病理生理过程常常伴随着细胞及细胞外基质硬度机械特性的变化。因此，Piezo1的表达可因机械刺激而上调，以驱动细胞内的生物学过程，这进而间接影响细胞微环境，导致细胞状态改变。另一方面，它可能与活性模式和/或亚细胞定位的变化产生矛盾效应。本综述重点介绍了Piezo1在CNS细胞中涉及的生物学过程，特别强调了其在胶质瘤相关表型中的多重作用。总之，在充分探索Piezo1在CNS疾病中的潜在机制后，Piezo1可作为评估胶质瘤患者恶性程度和预后的指标，以及临床应用的治疗靶点。
