Xu Yongwei, Zhang Bacui, Wang Jing
Department of Gastroenterology, Songjiang Hospital, School of Medicine, Shanghai Jiaotong University, No. 746, Zhongsanzhong Road, Songjiang District, Shanghai 201600, China.
Diagnostics (Basel). 2023 Jan 19;13(3):376. doi: 10.3390/diagnostics13030376.
Gastrointestinal stromal tumour (GIST) is a malignant tumour of the gastrointestinal lobe tissue, which mostly occurs in the gastrointestinal tract. Clinical manifestations can range from being benign to malignant. It mainly occurs in the gastric and small intestine. It may also develop in the colon, oesophagus, and bowel membranes, or outside the gastrointestinal tract and intestines. The pathological diagnosis of GIST depends on morphological measurements and immunohistochemistry. We report an interesting case in which the patient's gastroscopy indicated gastric malignant tumours, and the results of the contrast-enhanced computed tomography (CT) of the upper abdomen showed malignant stomach tumour accompanied by liver metastasis. After the patient knew about this diagnosis, she wanted to give up treatment. Finally, the gastric biopsy suggested positive CD34, CD117, DOG1, and Ki-67, which supported the diagnosis of GIST. We hope that, through this case, we could improve clinicians' understanding of GIST and improve its diagnosis and treatment.
胃肠道间质瘤（GIST）是一种胃肠道叶组织的恶性肿瘤，多发生于胃肠道。临床表现可从良性到恶性。它主要发生在胃和小肠。也可能发生在结肠、食管和肠膜，或胃肠道和肠道外。GIST的病理诊断取决于形态学测量和免疫组织化学。我们报告一例有趣的病例，该患者的胃镜检查显示为胃恶性肿瘤，上腹部增强计算机断层扫描（CT）结果显示胃恶性肿瘤伴肝转移。患者得知该诊断后想放弃治疗。最后，胃活检显示CD34、CD117、DOG1和Ki-67呈阳性，支持GIST的诊断。我们希望通过这个病例，提高临床医生对GIST的认识，改善其诊断和治疗。
