Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, 8036 Graz, Austria.
Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Cells. 2023 Feb 2;12(3):480. doi: 10.3390/cells12030480.
Chronic obstructive pulmonary disease (COPD) serves as risk factor for the development of lung cancer and seems to have a prognostic impact after surgery for non-small cell lung cancer (NSCLC). The aim was to investigate the impact of COPD and postoperative mucostasis on the long-term survival after resected NSCLC. We retrospectively reviewed the data from 342 patients with curatively resected NSCLC. The prognostic long-term impact of COPD and postoperative mucostasis on overall survival (OS), recurrence free survival (RFS) and cancer specific survival (CSS) was calculated using univariable and multivariable Cox regression analyses. We found that 52.3% suffered from COPD and 25.4% had postoperative mucostasis. COPD was significantly more common among smokers (59.9%) compared with non-smokers (21.3%), ( < 0.001). There was a significant relationship between COPD and postoperative mucostasis ( = 0.006) and between smoking and mucostasis ( = 0.023). Patients with postoperative mucostasis had a significantly worse OS ( < 0.001), RFS ( = 0.009) and CSS ( = 0.008). The present analysis demonstrated that postoperative mucostasis, but not COPD, was associated with both worse short- and long-term outcomes for OS, RFS and CSS in curatively resected NSCLC.
慢性阻塞性肺疾病（COPD）是肺癌发生的危险因素，并且似乎对非小细胞肺癌（NSCLC）手术后的预后有影响。本研究旨在探讨 COPD 和术后黏液阻塞对 NSCLC 切除后长期生存的影响。我们回顾性分析了 342 例接受根治性 NSCLC 手术的患者的数据。使用单变量和多变量 Cox 回归分析计算 COPD 和术后黏液阻塞对总生存（OS）、无复发生存（RFS）和癌症特异性生存（CSS）的预后长期影响。我们发现，52.3%的患者患有 COPD，25.4%的患者发生术后黏液阻塞。与不吸烟者（21.3%）相比，吸烟者（59.9%）中 COPD 更为常见（<0.001）。COPD 与术后黏液阻塞（=0.006）以及吸烟与黏液阻塞（=0.023）之间存在显著关系。发生术后黏液阻塞的患者 OS（<0.001）、RFS（=0.009）和 CSS（=0.008）明显更差。本分析表明，术后黏液阻塞与 NSCLC 根治性切除术后 OS、RFS 和 CSS 的短期和长期预后较差相关，而 COPD 则无此相关性。
