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海伊勒地区的二甲双胍治疗与乳腺癌发病率

Metformin Therapy and Breast Cancer Incidence in the Ha'il Region.

作者信息

Osman Mhdia, Muqbel Taif, Abduallh Ahad, Alanazi Shuruq, Khalifa Nasrin E, Khojali Weam M A, Elagib Halima Mustafa, Hussein Weiam, Abdallah Marwa H

机构信息

Department of Clinical Pharmacy, Faculty of Pharmacy, University of Ha'il, P.O. Box 2440, Ha'il 55476, Saudi Arabia.

Student College of Pharmacy, University of Ha'il, Ha'il 55476, Saudi Arabia.

出版信息

Healthcare (Basel). 2023 Jan 20;11(3):321. doi: 10.3390/healthcare11030321.

DOI:10.3390/healthcare11030321
PMID:36766896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9914021/
Abstract

BACKGROUND

Metformin is a drug used to treat patients with type 2 diabetes, especially those who suffer from obesity. It is also used in the treatment of women with polycystic ovary syndrome (PCOS). This disease is related to insulin resistance and multiplied blood sugar ranges. Furthermore, it has been established that the use of metformin improves the menstrual cycles and ovulation rates of these women.

METHODS

A structured questionnaire was conducted to determine the prevalence of breast cancer among women using metformin in the Ha'il region.

RESULT

The incidence of breast cancer among women using metformin in the Ha'il region is very low. Thus, it can be said that breast cancer cases declined among diabetics taking metformin. This means that metformin use is associated with a lower risk of breast cancer in women with type 2 diabetes, even in cases where these women have a family history of breast cancer.

CONCLUSIONS

According to previous findings, metformin has been linked to lower breast cancer risk in women with type 2 diabetes. Furthermore, the findings of this study corroborate the literature on this subject by indicating that there is a substantial connection between metformin use and a lower risk of breast cancer in women with type 2 diabetes. However, further in vitro and in vivo experiments are crucial to investigate the protective effect of metformin against breast cancer and to confirm our findings.

摘要

背景

二甲双胍是一种用于治疗2型糖尿病患者的药物，尤其是那些患有肥胖症的患者。它也用于治疗患有多囊卵巢综合征（PCOS）的女性。这种疾病与胰岛素抵抗和血糖水平升高有关。此外，已经证实使用二甲双胍可改善这些女性的月经周期和排卵率。

方法

通过一份结构化问卷来确定海伊勒地区使用二甲双胍的女性中乳腺癌的患病率。

结果

海伊勒地区使用二甲双胍的女性中乳腺癌的发病率非常低。因此，可以说服用二甲双胍的糖尿病患者中乳腺癌病例有所减少。这意味着使用二甲双胍与2型糖尿病女性患乳腺癌的风险较低有关，即使这些女性有乳腺癌家族史。

结论

根据先前的研究结果，二甲双胍与2型糖尿病女性患乳腺癌风险较低有关。此外，本研究的结果通过表明使用二甲双胍与2型糖尿病女性患乳腺癌风险较低之间存在实质性联系，证实了关于该主题的文献。然而，进一步的体外和体内实验对于研究二甲双胍对乳腺癌的保护作用并证实我们的发现至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/fc93c4b454fb/healthcare-11-00321-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/d76746ac43e2/healthcare-11-00321-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/174a5eb22764/healthcare-11-00321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/38784819bdbf/healthcare-11-00321-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/4fbf6447e58e/healthcare-11-00321-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/3a60c6bbb8f0/healthcare-11-00321-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/44f644abf50f/healthcare-11-00321-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/a4afcf1620c9/healthcare-11-00321-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/fc93c4b454fb/healthcare-11-00321-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/d76746ac43e2/healthcare-11-00321-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/174a5eb22764/healthcare-11-00321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/38784819bdbf/healthcare-11-00321-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/4fbf6447e58e/healthcare-11-00321-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/3a60c6bbb8f0/healthcare-11-00321-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/44f644abf50f/healthcare-11-00321-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/a4afcf1620c9/healthcare-11-00321-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/9914021/fc93c4b454fb/healthcare-11-00321-g007.jpg

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Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression.以乳腺癌为例，探讨肿瘤异质性和肿瘤细胞可塑性在恶性进展过程中的作用。
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Relationships are between metformin use and survival in pancreatic cancer patients concurrent with diabetes: A systematic review and meta-analysis.胰腺癌合并糖尿病患者使用二甲双胍与生存的关系：一项系统评价和荟萃分析。
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Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin.二甲双胍的免疫介导抗肿瘤作用；靶向 T 细胞的代谢重编程作为二甲双胍抗肿瘤作用的新可能机制。
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