Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Int J Mol Sci. 2023 Jan 19;24(3):1998. doi: 10.3390/ijms24031998.
The vascular endothelium plays a vital role during embryogenesis and aging and is a cell monolayer that lines the blood vessels. The immune system recognizes the endothelium as its own. Therefore, an abnormality of the endothelium exposes the tissues to the immune system and provokes inflammation and vascular diseases such as atherosclerosis. Its secretory role allows it to release vasoconstrictors and vasorelaxants as well as cardio-modulatory factors that maintain the proper functioning of the circulatory system. The sealing of the monolayer provided by adhesion molecules plays an important role in cardiovascular physiology and pathology.
血管内皮在胚胎发生和衰老过程中起着至关重要的作用，是排列在血管内的单层细胞。免疫系统将内皮视为自身的一部分。因此，内皮的异常会使组织暴露于免疫系统中，引发炎症和血管疾病，如动脉粥样硬化。它的分泌作用使其能够释放血管收缩剂和血管舒张剂以及心脏调节因子，以维持循环系统的正常功能。黏附分子提供的单层密封在心血管生理学和病理学中起着重要作用。
