Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Int J Mol Sci. 2022 Aug 29;23(17):9770. doi: 10.3390/ijms23179770.
Atherosclerosis is one of the key problems of modern medicine, which is due to the high prevalence of atherosclerotic cardiovascular diseases and their significant share in the structure of morbidity and mortality in many countries. Atherogenesis is a complex chain of events that proceeds over many years in the vascular wall with the participation of various cells. Endothelial cells are key participants in vascular function. They demonstrate involvement in the regulation of vascular hemodynamics, metabolism, and innate immunity, which act as leading links in the pathogenesis of atherosclerosis. These endothelial functions have close connections and deep evolutionary roots, a better understanding of which will improve the prospects of early diagnosis and effective treatment.
动脉粥样硬化是现代医学的关键问题之一，这是由于动脉粥样硬化性心血管疾病的高患病率及其在许多国家的发病率和死亡率结构中占有重要份额。动脉粥样硬化形成是一个复杂的事件链，在血管壁中经过多年的进展，涉及各种细胞。内皮细胞是血管功能的关键参与者。它们参与调节血管血液动力学、代谢和先天免疫，在动脉粥样硬化的发病机制中起着主导作用。这些内皮功能具有密切的联系和深刻的进化根源，更好地理解这些联系和根源将提高早期诊断和有效治疗的前景。
