定制超分子笼用于高效生物标记。
Tailored Supramolecular Cage for Efficient Bio-Labeling.
机构信息
College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
College of Chemistry and Chemical Engineering, Zhoukou Normal University, Zhoukou 466001, China.
出版信息
Int J Mol Sci. 2023 Jan 21;24(3):2147. doi: 10.3390/ijms24032147.
Fluorescent chemosensors are powerful imaging tools used in a broad range of biomedical fields. However, the application of fluorescent dyes in bioimaging still remains challenging, with small Stokes shifts, interfering signals, background noise, and self-quenching on current microscope configurations. In this work, we reported a supramolecular cage () by coordination-driven self-assembly of benzothiadiazole derivatives and Eu(OTf). The exhibited high fluorescence with a quantum yield (QY) of 38.57%, good photoluminescence (PL) stability, and a large Stokes shift (153 nm). Furthermore, the CCK-8 assay against U87 glioblastoma cells verified the low cytotoxicity of . We revealed that the designed probes could be used as U87 cells targeting bioimaging.
荧光化学传感器是一类在广泛的生物医学领域中被广泛应用的强大成像工具。然而，荧光染料在生物成像中的应用仍然具有挑战性，例如较小的斯托克斯位移、干扰信号、背景噪声以及当前显微镜配置下的自猝灭。在这项工作中，我们通过苯并噻二唑衍生物和 Eu(OTf) 的配位驱动自组装报告了一种超分子笼 ()。该超分子笼具有高荧光量子产率（QY）为 38.57%、良好的光致发光（PL）稳定性和大的斯托克斯位移（153nm）。此外，对 U87 神经胶质瘤细胞的 CCK-8 测定验证了 的低细胞毒性。我们揭示了设计的探针可以用作 U87 细胞靶向生物成像的探针。
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