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恒河猴胎儿大脑雄激素受体的性别和区域差异分析

Analysis of sex and regional differences in androgen receptors in fetal rhesus monkey brain.

作者信息

Pomerantz S M, Sholl S A

机构信息

Department of Physiology, University of Pittsburgh, PA 15261.

出版信息

Brain Res. 1987 Nov;433(1):151-4. doi: 10.1016/0165-3806(87)90074-5.

DOI:10.1016/0165-3806(87)90074-5
PMID:3676852
Abstract

Cytosolic androgen receptor levels were measured in different brain regions of fetal male and female rhesus monkeys (day 135 post-conception). The hypothalamus-preoptic area, amygdala and cerebellum exhibited higher receptor concentration in comparison to the cerebral cortex (parietal, temporal frontal, and occipital lobes), hippocampus and cingulate gyrus (P less than 0.001). No sexual difference in receptor concentrations was found except in the amygdala where fetal males exhibited slightly higher levels than females. The similarity in androgen receptor levels suggests that the developing brain of both sexes could be influenced by circulating androgens under normal or pathological conditions.

摘要

在怀孕135天的雄性和雌性恒河猴胎儿的不同脑区测量了胞质雄激素受体水平。与大脑皮层(顶叶、颞叶、额叶和枕叶)、海马体和扣带回相比,下丘脑视前区、杏仁核和小脑表现出更高的受体浓度(P<0.001)。除了杏仁核中雄性胎儿的受体水平略高于雌性外,未发现受体浓度存在性别差异。雄激素受体水平的相似性表明,在正常或病理条件下,两性发育中的大脑都可能受到循环雄激素的影响。

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