肝移植背景下肝细胞癌的免疫治疗：综述。
Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review.
机构信息
Division of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Department of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA.
出版信息
Int J Mol Sci. 2023 Jan 25;24(3):2358. doi: 10.3390/ijms24032358.
Abstract
The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points to the safety and efficacy of immunotherapeutic agents as potential adjuncts for successful down-staging of advanced HCCs to allow successful transplant in carefully selected patients. For patients with recurrent HCC post-transplant, immunotherapy has a limited, yet growing role. In this review, we describe optimal regimens in the setting of liver transplantation.
摘要
免疫肿瘤学这一新兴领域在肝细胞癌（HCC）治疗方面带来了令人兴奋的进展。它也提出了关于免疫疗法在肝移植前后的作用的紧迫问题。越来越多的证据表明免疫治疗药物的安全性和有效性可以作为成功降期晚期 HCC 的辅助手段，以使精心选择的患者能够成功进行移植。对于移植后复发 HCC 的患者，免疫疗法的作用有限，但正在不断发展。在这篇综述中，我们描述了肝移植中的最佳方案。
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