Liu Wei, Sun Jian, Shi Zhiyong, Huang Zheng, Yu Lebao, Du Haibin, Ge Peicong, Zhang Dong
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Department of Neurosurgery, Beijing Changping District Hospital, Beijing 100071, China.
J Clin Med. 2023 Jan 19;12(3):823. doi: 10.3390/jcm12030823.
Inflammation is a key factor in the development of moyamoya disease. However, the cytokine distribution in moyamoya disease and its impact on prognosis remain unclear. A total of 204 patients with moyamoya disease were enrolled in this study. The peripheral blood was analyzed for baseline data and cytokines, which included IL-6, IL-1β, IL-2R, IL-8, and TNF-α. Patients with the RNF213 mutation and those without the mutation were compared in terms of their differences in cytokines. A mRS score ≥2 was defined as a poor prognosis, and a mRS score <2 was described as a good prognosis, and differences in cytokines were compared between the two groups. Regression analysis was performed to identify markers affecting prognosis. TNF-α and IL-6 levels were higher in the group without the RNF213 mutation compared to the mutation group. Multivariate stepwise regression analysis indicated that the G3 subgroup of IL-6 and the G4 subgroup of TNF-α were the independent risk factors for adverse prognosis in adults with moyamoya disease (OR 3.678, 95% CI [1.491, 9.074], = 0.005; OR 2.996, 95% CI [1.180, 7.610], = 0.021). IL-6 and TNF-α were associated with poor prognosis in adult patients with moyamoya disease.
炎症是烟雾病发展的关键因素。然而，烟雾病中细胞因子的分布及其对预后的影响仍不清楚。本研究共纳入204例烟雾病患者。分析外周血的基线数据和细胞因子，包括白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、白细胞介素-2受体（IL-2R）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）。比较有RNF213突变的患者和无突变患者在细胞因子方面的差异。改良Rankin量表（mRS）评分≥2被定义为预后不良，mRS评分<2被描述为预后良好，并比较两组之间细胞因子的差异。进行回归分析以确定影响预后的标志物。与突变组相比，无RNF213突变组的TNF-α和IL-6水平更高。多因素逐步回归分析表明，IL-6的G3亚组和TNF-α的G4亚组是成人烟雾病不良预后的独立危险因素（比值比[OR]3.678，95%置信区间[CI][1.491，9.074]，P = 0.005；OR 2.996，95%CI[1.180，7.610]，P = 0.021）。IL-6和TNF-α与成人烟雾病患者的不良预后相关。
