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阿达木单抗对化脓性汗腺炎患者抗生素处方的影响:一项为期1年的前瞻性研究和回顾性分析。

How Adalimumab Impacts Antibiotic Prescriptions in Patients Affected by Hidradenitis Suppurativa: A 1-Year Prospective Study and Retrospective Analysis.

作者信息

Martora Fabrizio, Marasca Claudio, Picone Vincenzo, Fornaro Luigi, Megna Matteo, Fabbrocini Gabriella

机构信息

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Napoli, Italy.

Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale", 80131 Napoli, Italy.

出版信息

J Clin Med. 2023 Jan 20;12(3):837. doi: 10.3390/jcm12030837.

DOI:10.3390/jcm12030837
PMID:36769485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9917487/
Abstract

We conducted a one-year prospective study involving the enrollment of 58 patients with Hidradenitis Suppurativa. Through a retrospective analysis of data on the same patients, with reference to the year prior to the initiation of the anti-TNFα drug adalimumab, we aimed to show how the advent of this biologic therapy changes the number of days of antibiotic therapy, the number of flare-ups per year, and their duration in days, as well as the quality of life and perceived pain of patients.

摘要

我们开展了一项为期一年的前瞻性研究,纳入了58例化脓性汗腺炎患者。通过对同一批患者的数据进行回顾性分析,并参考抗TNFα药物阿达木单抗治疗开始前一年的情况,我们旨在展示这种生物疗法的出现如何改变抗生素治疗天数、每年的病情发作次数及其持续天数,以及患者的生活质量和疼痛感受。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/f5818e4c7b9c/jcm-12-00837-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/b7a20f199e35/jcm-12-00837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/3bcd11ba41e4/jcm-12-00837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/c05c53b169f0/jcm-12-00837-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/f5818e4c7b9c/jcm-12-00837-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/b7a20f199e35/jcm-12-00837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/3bcd11ba41e4/jcm-12-00837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/c05c53b169f0/jcm-12-00837-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc7e/9917487/f5818e4c7b9c/jcm-12-00837-g004.jpg

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How Adalimumab Impacts Antibiotic Prescriptions in Patients Affected by Hidradenitis Suppurativa: A 1-Year Prospective Study and Retrospective Analysis.阿达木单抗对化脓性汗腺炎患者抗生素处方的影响:一项为期1年的前瞻性研究和回顾性分析。
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本文引用的文献

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Clin Exp Dermatol. 2022 Nov;47(11):2026-2028. doi: 10.1111/ced.15306. Epub 2022 Aug 4.
2
A Case of Pemphigus Vulgaris and Hidradenitis Suppurativa: May Systemic Steroids Be Considered in the Standard Management of Hidradenitis Suppurativa?一例寻常型天疱疮合并化脓性汗腺炎:在化脓性汗腺炎的标准治疗中是否可考虑使用全身性类固醇?
Skin Appendage Disord. 2022 May;8(3):265-268. doi: 10.1159/000521712. Epub 2022 Jan 26.
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古塞库单抗、司库奇尤单抗和替拉珠单抗治疗化脓性汗腺炎:现有试验及真实世界数据综述
Clin Cosmet Investig Dermatol. 2023 Sep 18;16:2525-2536. doi: 10.2147/CCID.S418748. eCollection 2023.
4
Hidradenitis Suppurativa and JAK Inhibitors: A Review of the Published Literature.化脓性汗腺炎和 JAK 抑制剂:已发表文献综述。
Medicina (Kaunas). 2023 Apr 20;59(4):801. doi: 10.3390/medicina59040801.
Strategies adopted in a southern Italian referral centre to reduce adalimumab discontinuation: comment on 'Can we increase the drug survival time of biologic therapies in hidradenitis suppurativa?'.意大利南部一家转诊中心为减少阿达木单抗停药所采取的策略:对“我们能否延长化脓性汗腺炎生物治疗的药物存活时间?”的评论
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