Raets Lore, Van Hoorenbeeck Kim, Maes Toon, Vercammen Chris, De Block Christophe, Dirinck Eveline, Van Pottelbergh Inge, Wierckx Katrien, Laenen Annouschka, Bogaerts Annick, Mathieu Chantal, Benhalima Katrien
Department of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Department of Pediatrics, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Belgium.
J Clin Med. 2023 Jan 28;12(3):1025. doi: 10.3390/jcm12031025.
The Belgian Diabetes in Pregnancy follow-up study (BEDIP-FUS) aims to investigate the impact of body mass index (BMI), adiposity and different degrees of glucose intolerance on the metabolic profile and future risk for type 2 diabetes (T2D) in women and offspring five years after delivery in the BEDIP study. The BEDIP study was a prospective cohort study to evaluate different screening strategies for gestational diabetes (GDM) based on the 2013 WHO criteria. The aim of the BEDIP-FUS is to recruit 375 women-offspring pairs, stratified according to three different subgroups based on the antenatal result of the glucose challenge test (GCT) and oral glucose tolerance test (OGTT) during the BEDIP pregnancy. The follow-up visit consists of a 75 g OGTT, anthropometric measurements and questionnaires for the mothers, and a fasting blood sample with anthropometric measurements for the child. Primary outcome for the mother is glucose intolerance defined by the American Diabetes Association criteria and for the offspring the BMI z-score. Recruitment began in January 2021. The BEDIP-FUS study will help to better individualize follow-up in women with different degrees of hyperglycemia in pregnancy and their offspring.
比利时孕期糖尿病随访研究（BEDIP - FUS）旨在调查体重指数（BMI）、肥胖程度以及不同程度的葡萄糖耐量异常对BEDIP研究中女性及其后代产后五年的代谢状况和2型糖尿病（T2D）未来发病风险的影响。BEDIP研究是一项前瞻性队列研究，旨在根据2013年世界卫生组织标准评估妊娠期糖尿病（GDM）的不同筛查策略。BEDIP - FUS的目标是招募375对母婴，根据BEDIP孕期葡萄糖耐量试验（GCT）和口服葡萄糖耐量试验（OGTT）的产前结果分为三个不同亚组。随访包括一次75克OGTT、对母亲进行人体测量和问卷调查，以及对孩子进行空腹血样采集和人体测量。母亲的主要结局指标是根据美国糖尿病协会标准定义的葡萄糖耐量异常，孩子的主要结局指标是BMI z评分。招募工作于2021年1月开始。BEDIP - FUS研究将有助于更好地针对孕期不同程度高血糖的女性及其后代进行个体化随访。
