Grigsby P W, Thomas P R, Schwartz H G, Fineberg B
Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, Missouri.
Cancer. 1987 Dec 15;60(12):2901-6. doi: 10.1002/1097-0142(19871215)60:12<2901::aid-cncr2820601210>3.0.co;2-w.
A retrospective analysis of 70 pediatric patients (less than 16 years of age) with histologically proven or presumed primary neoplasms of the thalamus, hypothalamus, and brainstem, treated with combined surgery and postoperative radiotherapy or radiotherapy alone at the Washington University Medical Center from January 1950 through December 1983, is reported. Overall survival for all patients at 5 and 10 years was 34.9% and 32.7%, respectively. Follow-up of the 22 surviving patients ranged from 3.0 to 20.0 years (median, 10.6 years). Statistical analysis of multiple prognostic factors was performed. Prognostic factors found by single variate analysis to significantly influence survival were primary site of disease, extent of surgery, race, cranial nerve paresis at diagnosis, and dose of radiation. Factors evaluated but found to be insignificant were age at diagnosis, duration of symptoms before diagnosis, sex, and volume irradiated. Multivariate analysis revealed that only total radiation dose and race were of prognostic significance.
报告了对1950年1月至1983年12月期间在华盛顿大学医学中心接受手术联合术后放疗或单纯放疗的70例小儿患者（年龄小于16岁）进行的回顾性分析，这些患者的丘脑、下丘脑和脑干原发性肿瘤经组织学证实或推测。所有患者5年和10年的总生存率分别为34.9%和32.7%。对22例存活患者的随访时间为3.0至20.0年（中位数为10.6年）。进行了多种预后因素的统计分析。单变量分析发现对生存有显著影响的预后因素是疾病的原发部位、手术范围、种族、诊断时的颅神经麻痹以及放疗剂量。评估但发现无统计学意义的因素是诊断时的年龄、诊断前症状持续时间、性别以及照射体积。多变量分析显示只有总放疗剂量和种族具有预后意义。
