Inaji H, Yayoi E, Maeura Y, Matsuura N, Tominaga S, Koyama H, Takatsuka Y, Mori T
Second Department of Surgery, Osaka University Medical School, Japan.
Cancer. 1987 Dec 15;60(12):3008-13. doi: 10.1002/1097-0142(19871215)60:12<3008::aid-cncr2820601225>3.0.co;2-l.
To assess the usefulness of carcinoembryonic antigen (CEA) estimation in nipple discharge for the detection of nonpalpable breast cancer, CEA activity in nipple discharge was measured by enzyme immunoassay using monoclonal antibody. The specificity of the antibody for breast cancer was assessed by an immunohistochemical method. Mean CEA levels in the nipple discharge from 18 patients with benign breast diseases (ten intraductal papilloma; eight fibrocystic disease) was 43 ng/ml (SD, 34 ng/ml), suggesting an upper reference limit of 100 ng/ml. Six of seven nonpalpable breast cancer patients had higher CEA levels than this tentative cutoff value, as did three of five patients with borderline lesions. The incidence of elevated CEA levels in nipple discharge correlated significantly with the incidence of intratumoral antigen expression. These results lead us to conclude that CEA measurement in nipple discharge may be a useful adjunct in the diagnosis of nonpalpable breast cancer.
为评估癌胚抗原（CEA）测定在乳头溢液检测不可触及乳腺癌中的应用价值，采用单克隆抗体酶免疫测定法检测乳头溢液中的CEA活性。通过免疫组化方法评估该抗体对乳腺癌的特异性。18例良性乳腺疾病患者（10例导管内乳头状瘤；8例纤维囊性疾病）乳头溢液中的CEA平均水平为43 ng/ml（标准差，34 ng/ml），提示参考上限为100 ng/ml。7例不可触及乳腺癌患者中有6例的CEA水平高于该暂定临界值，5例临界病变患者中有3例也是如此。乳头溢液中CEA水平升高的发生率与肿瘤内抗原表达的发生率显著相关。这些结果使我们得出结论，乳头溢液中CEA的测定可能是诊断不可触及乳腺癌的一种有用辅助手段。
