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用抗菌剂和新型SufA蛋白酶抑制剂功能化的活性炭的性质

The Properties of Activated Carbons Functionalized with an Antibacterial Agent and a New SufA Protease Inhibitor.

作者信息

Burchacka Ewa, Pstrowska Katarzyna, Bryk Michał, Maciejowski Filip, Kułażyński Marek, Chojnacka Katarzyna

机构信息

Department of Chemistry, Wroclaw University of Science and Technology, Wyspiańskiego Str. 27, 50-370 Wroclaw, Poland.

Innovation and Implementation Company Ekomotor Ltd., 1A Wyścigowa Street, 53-011 Wroclaw, Poland.

出版信息

Materials (Basel). 2023 Feb 1;16(3):1263. doi: 10.3390/ma16031263.

Abstract

is the cause of many diseases, including numerous infections of the skin. One way to help combat skin infections is to use bandages containing activated carbon. Currently, there are no dressings on the market that use the synergistic effect of activated carbon and antibiotics. Thus, in this study, we point out the adsorption level of an antimicrobial substance on three different active carbons of different origins; by examining the inhibition level of the growth of bacteria, we determined the number of live cells adsorbed on activated carbons depending on the presence of gentamicin in the solution. In addition, we designed and synthesized a new antibacterial substance with a new mechanism of action to act as a bacterial protease inhibitor, as well as determining the antibacterial properties conducted through adsorption. Our results demonstrate that activated carbons with adsorbed antibiotics show better bactericidal properties than activated carbon alone or the antibiotic itself. The use of properly modified activated carbons may have a beneficial effect on the development and functioning of new starting materials for bacteria elimination, e.g., in wound-healing treatments in the future.

摘要

它是许多疾病的病因,包括众多皮肤感染。对抗皮肤感染的一种方法是使用含有活性炭的绷带。目前,市场上没有利用活性炭和抗生素协同作用的敷料。因此,在本研究中,我们指出了抗菌物质在三种不同来源的活性炭上的吸附水平;通过检测细菌生长的抑制水平,我们根据溶液中庆大霉素的存在情况确定了吸附在活性炭上的活细胞数量。此外,我们设计并合成了一种具有新作用机制的新型抗菌物质,用作细菌蛋白酶抑制剂,并确定了通过吸附进行的抗菌性能。我们的结果表明,吸附有抗生素的活性炭比单独的活性炭或抗生素本身具有更好的杀菌性能。使用经过适当改性的活性炭可能会对未来用于消除细菌的新型起始材料的开发和功能产生有益影响,例如在伤口愈合治疗中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9b/9920905/b41d76f9d619/materials-16-01263-sch001.jpg

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