癌症患者的血清脂质和脂蛋白紊乱

Serum lipids and lipoprotein disorders in cancer patients.

作者信息

Alexopoulos C G, Blatsios B, Avgerinos A

机构信息

Second Professoral Unit, Athens University, Evangelismos Hospital, Greece.

出版信息

Cancer. 1987 Dec 15;60(12):3065-70. doi: 10.1002/1097-0142(19871215)60:12<3065::aid-cncr2820601234>3.0.co;2-q.

DOI:10.1002/1097-0142(19871215)60:12<3065::aid-cncr2820601234>3.0.co;2-q

PMID:3677028

Abstract

Total serum cholesterol, free and esterified cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, serum triglycerides and serum lipoproteins were measured in 103 consecutive cancer patients (60 men and 43 women; mean age, 56 years) and 100 age-matched noncancer inpatients. Cancer patients as a group demonstrated significantly lower total cholesterol, esterified cholesterol and LDL cholesterol, compared with noncancer patients. Breast cancer proved to be an exception associated with increased serum total cholesterol, free cholesterol, LDL cholesterol, and triglycerides. a-lipoproteins were constantly increased in cancer patients whereas no differences were found in the other lipoprotein fractions. Finally, the observed overall incidence of hyperlipidemia in cancer patients (23/103) was not significantly different from the controls (29/100).

摘要

对103例连续的癌症患者（60名男性和43名女性；平均年龄56岁）和100名年龄匹配的非癌症住院患者测定了血清总胆固醇、游离胆固醇和酯化胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇、血清甘油三酯和血清脂蛋白。与非癌症患者相比，癌症患者作为一个群体的总胆固醇、酯化胆固醇和LDL胆固醇显著降低。乳腺癌被证明是一个例外，与血清总胆固醇、游离胆固醇、LDL胆固醇和甘油三酯升高有关。癌症患者的α脂蛋白持续升高，而其他脂蛋白组分未发现差异。最后，癌症患者中观察到的高脂血症总体发生率（23/103）与对照组（29/100）无显著差异。