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糖聚合物在抗菌和抗病毒方面的应用。

Glycopolymers for Antibacterial and Antiviral Applications.

机构信息

Center for Soft Condensed Matter Physics and Interdisciplinary Research, School of Physical Science and Technology, Soochow University, Suzhou 215006, China.

Key Laboratory of Polymeric Material Design and Synthesis for Biomedical Function, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou 215123, China.

出版信息

Molecules. 2023 Jan 18;28(3):985. doi: 10.3390/molecules28030985.

DOI:10.3390/molecules28030985
PMID:36770653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9919862/
Abstract

Diseases induced by bacterial and viral infections are common occurrences in our daily life, and the main prevention and treatment strategies are vaccination and taking antibacterial/antiviral drugs. However, vaccines can only be used for specific viral infections, and the abuse of antibacterial/antiviral drugs will create multi-drug-resistant bacteria and viruses. Therefore, it is necessary to develop more targeted prevention and treatment methods against bacteria and viruses. Proteins on the surface of bacteria and viruses can specifically bind to sugar, so glycopolymers can be used as potential antibacterial and antiviral drugs. In this review, the research of glycopolymers for bacterial/viral detection/inhibition and antibacterial/antiviral applications in recent years are summarized.

摘要

由细菌和病毒感染引起的疾病在我们的日常生活中很常见，主要的预防和治疗策略是接种疫苗和服用抗菌/抗病毒药物。然而，疫苗只能用于特定的病毒感染，抗菌/抗病毒药物的滥用会产生多药耐药细菌和病毒。因此，有必要开发针对细菌和病毒的更有针对性的预防和治疗方法。细菌和病毒表面的蛋白质可以特异性地与糖结合，因此糖聚合物可以用作潜在的抗菌和抗病毒药物。本文综述了近年来糖聚合物在细菌/病毒检测/抑制以及抗菌/抗病毒应用方面的研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83fb/9919862/bae90ba9c2ad/molecules-28-00985-g017.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83fb/9919862/67ca1feee257/molecules-28-00985-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83fb/9919862/e2651501d250/molecules-28-00985-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83fb/9919862/155e071e64f1/molecules-28-00985-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83fb/9919862/6ad6b5b6fdfc/molecules-28-00985-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83fb/9919862/1344b1dce193/molecules-28-00985-g014.jpg
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