甘露醇是喷雾干燥羟丙基-β-环糊精微胶囊的优良抗结块剂。
Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules.
机构信息
Collaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, China.
Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 200051, China.
出版信息
Molecules. 2023 Jan 22;28(3):1119. doi: 10.3390/molecules28031119.
Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flowability and lower hygroscopicity and exhibited good anticaking properties. Mechanism research revealed that CaSt, MgSt, and SiO reduce hygroscopicity and caking by increasing the glass transition temperature of the microcapsules, while MAN prevents the hydroxyl group of HP-β-CD from combining with water molecules in the air by a crystal outer-layer on the microcapsule surface.
团聚是喷雾干燥微胶囊粉末中经常出现的一种不良现象。本工作的目的是从四种抗结块剂（硬脂酸钙（CaSt）、硬脂酸镁（MgSt）、二氧化硅（SiO）和甘露醇（MAN））中确定喷雾干燥羟丙基-β-环糊精（HP-β-CD）微胶囊的最佳解决方案，并探讨其抗结块机制。结果表明，MAN 被发现是四种抗结块剂中性能最优的。当 MAN 比例为 12%时，具有特殊苍耳型形状的微胶囊具有更高的粉末流动性和更低的吸湿性，并表现出良好的抗结块性能。机理研究表明，CaSt、MgSt 和 SiO 通过提高微胶囊的玻璃化转变温度来降低吸湿性和结块性，而 MAN 通过在微胶囊表面形成晶体外层来阻止 HP-β-CD 的羟基与空气中的水分子结合。
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