Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, Poland.
Molecules. 2023 Jan 25;28(3):1195. doi: 10.3390/molecules28031195.
In this study, nine forced degradation products of maraviroc were found using chemometric analysis. This antiretroviral drug was subjected to photolytic, oxidative, as well as neutral, basic and acidic hydrolysis stress conditions. Additionally, its electrochemical transformation on platinum, gold and glassy carbon screen-printed electrodes was examined. This study showed that maraviroc is especially susceptible to UVA, HO and electrochemical degradation, while being resistant to neutral and acidic hydrolysis. A cluster analysis showed that the electrochemical transformation, with particular reference to the platinum electrode, is able to partially simulate the forced degradation processes, especially in the context of redox reactions. These findings indicate that the electrochemical methods can be considered as quick and relatively low-cost supplements to the commonly applied forced degradation procedures.
在这项研究中，使用化学计量分析发现了马拉维若的九个强制降解产物。这种抗逆转录病毒药物经历了光解、氧化以及中性、碱性和酸性水解的应激条件。此外，还研究了其在铂、金和玻璃碳丝网印刷电极上的电化学转化。本研究表明，马拉维若特别容易受到 UVA、HO 和电化学降解的影响，而对中性和酸性水解具有抗性。聚类分析表明，电化学转化，特别是针对铂电极，能够部分模拟强制降解过程，特别是在氧化还原反应方面。这些发现表明，电化学方法可以被视为对常用强制降解程序的快速且相对低成本的补充。
