Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan.
Yaizu Suisankagaku Industry Co., Ltd., 5-8-13 Kogawa-shimmachi, Yaizu, Shizuoka 425-8570, Japan.
Nutrients. 2023 Jan 18;15(3):503. doi: 10.3390/nu15030503.
L-fucose (Fuc), a monosaccharide with different biological functions in various organisms, exhibits potent anti-obesity effects in obese mice. However, the mechanisms underlying its anti-obesity effects remain largely unknown. In this study, we aimed to investigate the effects of Fuc on lipid metabolism and insulin signaling in 3T3-L1 adipocytes. We found that Fuc treatment suppressed lipid accumulation during adipocyte differentiation. Additionally, Fuc treatment enhanced the phosphorylation of AMP-activated kinase (AMPK) and its downstream pathways, responsible for the regulation of fatty acid oxidation and lipolysis. Furthermore, Fuc-induced activation of the AMPK pathway was diminished by the AMPK inhibitor Compound C, and Fuc treatment considerably promoted glucose uptake via Akt activation in an insulin-resistant state. These findings provide a basis for elucidating the mechanism underlying the anti-obesity effect of Fuc, which may, in the future, be considered as a therapeutic compound for treating obesity and related diseases.
岩藻糖（Fuc）是一种在各种生物体中具有不同生物学功能的单糖，在肥胖小鼠中表现出很强的抗肥胖作用。然而，其抗肥胖作用的机制在很大程度上尚不清楚。在本研究中，我们旨在研究 Fuc 对 3T3-L1 脂肪细胞中脂质代谢和胰岛素信号的影响。我们发现 Fuc 处理可抑制脂肪细胞分化过程中的脂质积累。此外，Fuc 处理增强了 AMP 激活的蛋白激酶（AMPK）及其下游途径的磷酸化，这些途径负责调节脂肪酸氧化和脂肪分解。此外，AMPK 抑制剂 Compound C 减弱了 Fuc 诱导的 AMPK 途径的激活，并且 Fuc 处理通过 Akt 激活在胰岛素抵抗状态下显著促进葡萄糖摄取。这些发现为阐明 Fuc 抗肥胖作用的机制提供了依据，将来可能被视为治疗肥胖症和相关疾病的治疗化合物。
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