肥胖相关的代谢炎症与胰岛素抵抗
Metabolic Inflammation and Insulin Resistance in Obesity.
机构信息
From the Department of Medicine (H.W., C.M.B.), Baylor College of Medicine, Houston, TX.
Department of Pediatrics (H.W.), Baylor College of Medicine, Houston, TX.
出版信息
Circ Res. 2020 May 22;126(11):1549-1564. doi: 10.1161/CIRCRESAHA.119.315896. Epub 2020 May 21.
Abstract
Obesity is becoming an epidemic in the United States and worldwide and increases risk for many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. The mechanisms linking obesity with these diseases remain incompletely understood. Over the past 2 to 3 decades, it has been recognized that in obesity, inflammation, with increased accumulation and inflammatory polarization of immune cells, takes place in various tissues, including adipose tissue, skeletal muscle, liver, gut, pancreatic islet, and brain and may contribute to obesity-linked metabolic dysfunctions, leading to insulin resistance and type 2 diabetes mellitus. Therapies targeting inflammation have shed light on certain obesity-linked diseases, including type 2 diabetes mellitus and atherosclerotic cardiovascular disease, but remain to be tested further and confirmed in clinical trials. This review focuses on inflammation in adipose tissue and its potential role in insulin resistance associated with obesity.
摘要
肥胖在美国和全球范围内正成为一种流行疾病，它会增加许多疾病的风险，特别是胰岛素抵抗、2 型糖尿病和心血管疾病。将肥胖与这些疾病联系起来的机制仍不完全清楚。在过去的 2 到 3 十年中，人们已经认识到，在肥胖中，炎症伴随着免疫细胞的积累和炎症极化，发生在各种组织中，包括脂肪组织、骨骼肌、肝脏、肠道、胰岛和大脑，并可能导致与肥胖相关的代谢功能障碍，导致胰岛素抵抗和 2 型糖尿病。针对炎症的治疗方法为某些与肥胖相关的疾病提供了线索，包括 2 型糖尿病和动脉粥样硬化性心血管疾病，但仍需在临床试验中进一步测试和证实。这篇综述重点介绍了脂肪组织中的炎症及其在肥胖相关胰岛素抵抗中的潜在作用。
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