Neonatal Intensive Care Unit, Schneider Children's Medical Center, Petah Tikva 4920235, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Sensors (Basel). 2023 Jan 28;23(3):1434. doi: 10.3390/s23031434.
On average, arterial oxygen saturation measured by pulse oximetry (SpO) is higher in hypoxemia than the true oxygen saturation measured invasively (SaO), thereby increasing the risk of occult hypoxemia. In the current article, measurements of SpO on 17 cyanotic newborns were performed by means of a Nellcor pulse oximeter (POx), based on light with two wavelengths in the red and infrared regions (660 and 900 nm), and by means of a novel POx, based on two wavelengths in the infrared region (761 and 820 nm). The SpO readings from the two POxs showed higher values than the invasive SaO readings, and the disparity increased with decreasing SaO. SpO measured using the two infrared wavelengths showed better correlation with SaO than SpO measured using the red and infrared wavelengths. After appropriate calibration, the standard deviation of the individual SpO-SaO differences for the two-infrared POx was smaller (3.6%) than that for the red and infrared POx (6.5%, < 0.05). The overestimation of SpO readings in hypoxemia was explained by the increase in hypoxemia of the optical pathlengths-ratio between the two wavelengths. The two-infrared POx can reduce the overestimation of SpO measurement in hypoxemia and the consequent risk of occult hypoxemia, owing to its smaller increase in pathlengths-ratio in hypoxemia.
平均而言，脉搏血氧饱和度仪（SpO）测量的动脉血氧饱和度在低氧血症中高于侵入性测量的实际氧饱和度（SaO），从而增加了隐匿性低氧血症的风险。在本文中，通过Nellcor 脉搏血氧仪（POx）对 17 名发绀新生儿进行了 SpO 测量，该 POx 基于红光和红外光的两个波长（660 和 900nm），以及一种新型的 POx，基于两个红外波长（761 和 820nm）。两种 POx 的 SpO 读数高于侵入性 SaO 读数，并且随着 SaO 的降低差异增大。与使用红光和红外光测量的 SpO 相比，使用两个红外波长测量的 SpO 与 SaO 相关性更好。经过适当校准后，两个红外波长 POx 的个体 SpO-SaO 差异的标准差（3.6%）小于红光和红外光 POx（6.5%，<0.05）。在低氧血症中 SpO 读数的高估是由两个波长之间的光程长度比的低氧血症增加引起的。由于在低氧血症中路径长度比的增加较小，因此两个红外波长 POx 可以减少 SpO 测量在低氧血症中的高估以及由此导致的隐匿性低氧血症的风险。
