Department of Endocrinology and Metabolism, Atılım Üniversitesi Tıp Fakültesi, Kızılcaşarİncek Gölbaşı, 06830, Ankara, Turkey.
Department of Physiology, Medical School, Atilim University, and Vocational School of Health Services, Atilim University, Ankara, Turkey.
Int Urol Nephrol. 2023 Jul;55(7):1821-1828. doi: 10.1007/s11255-023-03475-7. Epub 2023 Feb 11.
To elucidate the association of serum irisin levels with bone mineral density (BMD) and calcium-phosphorus metabolism parameters in chronic kidney disease (CKD) patients and renal transplant recipients (RTRs).
This is a cross-sectional study involving CKD patients and RTRs. Healthy volunteers served as controls. Age, gender, and dialysis vintage were recorded. Serum irisin, creatinine, glucose, calcium, albumin, 25(OH) vitamin D, ferritin, C-reactive protein, A1C, and lipid profile were studied in all participants. Estimated glomerular filtration rate (eGFR), corrected calcium, and body mass index (BMI) were calculated.
Overall, 49 patients (23 hemodialysis, 26 RTRs) and 25 control subjects were included. In hemodialysis (HD) group, 8 patients (34.8%) had osteoporosis, and 12 patients (52.2%) had osteopenia. In RTR group, 3 patients (11.5%) had osteoporosis, while 15 patients (57.7%) had osteopenia. Among controls, one had osteoporosis, and 7 had osteopenia. There was no significant difference between HD and RTRs; however, osteoporosis rate was significantly lower in control subjects. BMD measurements (femur and lumbar T- and Z-scores) were comparable between HD and RTR groups. Control group DEXA values were similar to RTRs; however, they were significantly higher compared to HD group. 25(OH) vitamin D levels were comparable between the HD and RTR groups, and these were significantly lower compared to values of the control group. Mean serum irisin level was 426.6 ± 191.2 pg/mL in hemodialysis group, 342.6 ± 174.8 in the RTR group, and 208.0 ± 186.1 in controls. Serum irisin levels were similar in RTR and HD groups, but their values were significantly higher compared to controls. When we compared serum irisin levels between patients with and without osteoporosis in the whole cohort and hemodialysis and RTR groups, there was no difference. Serum irisin was positively correlated with lumbar T-score both in hemodialysis and RTR groups.
Our study is the first in the literature revealing the positive correlation of serum irisin level with femur T-score in RTRs. Serum irisin level was also positively correlated with femur T-scores in hemodialysis patients.
探讨血清鸢尾素水平与慢性肾脏病（CKD）患者和肾移植受者（RTR）的骨密度（BMD）和钙磷代谢参数的关系。
这是一项涉及 CKD 患者和 RTR 的横断面研究。健康志愿者作为对照。记录年龄、性别和透析龄。所有参与者均检测血清鸢尾素、肌酐、葡萄糖、钙、白蛋白、25（OH）维生素 D、铁蛋白、C 反应蛋白、A1C 和血脂谱。计算估计肾小球滤过率（eGFR）、校正钙和体重指数（BMI）。
共纳入 49 例患者（23 例血液透析，26 例 RTR）和 25 例对照。在血液透析（HD）组中，8 例（34.8%）患者患有骨质疏松症，12 例（52.2%）患者患有骨量减少症。在 RTR 组中，3 例（11.5%）患者患有骨质疏松症，而 15 例（57.7%）患者患有骨量减少症。对照组中，1 例患有骨质疏松症，7 例患有骨量减少症。HD 组和 RTR 组之间无显著差异；然而，对照组的骨质疏松症发生率明显较低。HD 组和 RTR 组的 BMD 测量值（股骨和腰椎 T-和 Z 评分）相似。对照组的 DEXA 值与 RTR 相似；然而，与 HD 组相比，这些值明显更高。HD 组和 RTR 组的 25（OH）维生素 D 水平相似，与对照组相比明显较低。血液透析组平均血清鸢尾素水平为 426.6±191.2pg/mL，RTR 组为 342.6±174.8pg/mL，对照组为 208.0±186.1pg/mL。RTR 组和 HD 组的血清鸢尾素水平相似，但明显高于对照组。当我们比较整个队列以及血液透析和 RTR 组中骨质疏松症患者和非骨质疏松症患者的血清鸢尾素水平时，没有差异。血清鸢尾素与整个队列和血液透析组的腰椎 T 评分呈正相关。
我们的研究首次揭示了血清鸢尾素水平与 RTR 股骨 T 评分之间的正相关。血清鸢尾素水平与血液透析患者的股骨 T 评分也呈正相关。
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