Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, Italy.
Int J Mol Sci. 2022 Jan 8;23(2):690. doi: 10.3390/ijms23020690.
Irisin is a peptide secreted by skeletal muscle following exercise that plays an important role in bone metabolism. Numerous experiments in vitro and in mouse models have shown that the administration of recombinant irisin promotes osteogenesis, protects osteocytes from dexamethasone-induced apoptosis, prevents disuse-induced loss of bone and muscle mass, and accelerates fracture healing. Although some aspects still need to be elucidated, such as the dose- and frequency-dependent effects of irisin in cell cultures and mouse models, ample clinical evidence is emerging to support its physiological relevance on bone in humans. A reduction in serum irisin levels, associated with an increased risk of osteoporosis and bone fractures, was observed in postmenopausal women and in both men and women during aging, Recently, cohort studies of subjects with secondary osteoporosis showed that these patients have lower circulating levels of irisin, suggesting that this myokine could be a novel marker to monitor bone quality in this disease. Although there are still few studies, this review discusses the emerging data that are highlighting the involvement of irisin in some diseases that cause secondary osteoporosis.
鸢尾素是一种在运动后由骨骼肌分泌的肽，在骨代谢中发挥重要作用。大量的体外实验和小鼠模型实验表明，重组鸢尾素的给药促进成骨作用，保护破骨细胞免受地塞米松诱导的凋亡，防止废用性骨和肌肉质量的损失，并加速骨折愈合。尽管有些方面仍需要阐明，如鸢尾素在细胞培养和小鼠模型中的剂量和频率依赖性作用，但越来越多的临床证据支持其在人类骨骼中的生理相关性。绝经后妇女和衰老过程中男女的血清鸢尾素水平降低，与骨质疏松症和骨折风险增加有关。最近，对继发性骨质疏松症患者的队列研究表明，这些患者的循环鸢尾素水平较低，提示这种肌因子可能是监测该疾病骨质量的一种新标志物。尽管研究仍较少，但本综述讨论了一些新兴数据，这些数据强调了鸢尾素在一些导致继发性骨质疏松症的疾病中的作用。
