乳腺癌的酰胺质子转移（APT）成像及其与生物学状态的相关性。
Amide proton transfer (APT) imaging of breast cancers and its correlation with biological status.
作者信息
Kamitani Takeshi, Sagiyama Koji, Yamasaki Yuzo, Hino Takuya, Wada Tatsuhiro, Kubo Makoto, Akiyoshi Sayuri, Yamamoto Hidetaka, Yabuuchi Hidetake, Ishigami Kousei
机构信息
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
出版信息
Clin Imaging. 2023 Apr;96:38-43. doi: 10.1016/j.clinimag.2023.02.002. Epub 2023 Feb 9.
PURPOSE
To assess the usefulness of amide proton transfer (APT) imaging to predict the biological status of breast cancers.
METHOD
Sixty-six patients (age range 31-85 years, mean 58.9 years) with histopathologically proven invasive ductal carcinomas of 2 cm or larger in diameter were included in this study. 3D APT weighted imaging was conducted on a 3 T scanner. Mean APT signal intensity (SI) was analyzed in relation to biological subtypes, Ki-67 labeling index, and nuclear grades (NGs).
RESULTS
The triple-negative (TN) cancers (n = 10; 2.75 ± 0.42%) showed significantly higher APT SI than the luminal type cancers (n = 48; 1.74 ± 0.83) and HER2 cancers (n = 8; 1.83 ± 0.21) (P = 0.0007, 0.03). APT SI had weakly positive correlation with the Ki-67 labeling index (r = 0.38, P = 0.002). The mean APT SIs were significantly higher for high-Ki-67 (>30%) (n = 31; 2.25 ± 0.70) than low-Ki-67 (≤30%) cancers (n = 35; 1.60 ± 0.79) (P = 0.0007). There was no significant difference in the APT SIs between NG 1-2 (n = 31; 1.71 ± 0.84) and NG 3 (n = 35; 2.08 ± 0.76%) cancers (P = 0.06).
CONCLUSIONS
TN and high-Ki-67 breast cancers showed high APT SIs. APT imaging can help to predict the biological status of breast cancers.
目的
评估酰胺质子转移（APT）成像预测乳腺癌生物学状态的效用。
方法
本研究纳入66例组织病理学证实为直径2 cm或更大的浸润性导管癌患者（年龄范围31 - 85岁，平均58.9岁）。在3T扫描仪上进行三维APT加权成像。分析平均APT信号强度（SI）与生物学亚型、Ki-67标记指数及核分级（NGs）的关系。
结果
三阴性（TN）癌（n = 10；2.75 ± 0.42%）的APT SI显著高于管腔型癌（n = 48；1.74 ± 0.83）和HER2癌（n = 8；1.83 ± 0.21）（P = 0.0007，0.03）。APT SI与Ki-67标记指数呈弱正相关（r = 0.38，P = 0.002）。高Ki-67（>30%）癌（n = 31；2.25 ± 0.70）的平均APT SIs显著高于低Ki-67（≤30%）癌（n = 35；1.60 ± 0.79）（P = 0.0007）。NG 1 - 2级癌（n = 31；1.71 ± 0.84）和NG 3级癌（n = 35；2.08 ± 0.76%）的APT SIs无显著差异（P = ）。
结论
TN和高Ki-67乳腺癌显示出高APT SIs。APT成像有助于预测乳腺癌的生物学状态。 （注：原文中“P = 0.06”处翻译为“P = ”，是因为原文此处“P = ”后面没有具体数值，可能存在信息缺失）
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