C反应蛋白-白蛋白-淋巴细胞（CALLY）指数对结直肠癌肝转移肝切除术后预后的影响
Impact of C-reactive protein-albumin-lymphocyte (CALLY) index on prognosis after hepatectomy for colorectal liver metastasis.
作者信息
Furukawa Kenei, Tsunematsu Masashi, Tanji Yoshiaki, Ishizaki Shunta, Akaoka Munetoshi, Haruki Koichiro, Uwagawa Tadashi, Onda Shinji, Matsumoto Michinori, Ikegami Toru
机构信息
Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
出版信息
Surg Oncol. 2023 Apr;47:101911. doi: 10.1016/j.suronc.2023.101911. Epub 2023 Feb 8.
AIM
The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel inflammation-based biomarker. We aimed to investigate whether the CALLY can predict the prognosis in patients with colorectal liver metastases (CRLM) after hepatic resection.
METHODS
We included 183 patients with CRLM who underwent hepatectomy. The CALLY index was defined as (albumin × lymphocytes)/(CRP × 10). We investigated the association of the CALLY index with overall survival by univariate and multivariate analyses.
RESULTS
In total, 101 (55%) patients had a low CALLY index (<4). In the univariate analysis, overall survival was significantly worse in patients with lymph node metastases (p = 0.02), extrahepatic lesions (p < 0.01), and a low CALLY index (p < 0.01). In the multivariate analysis, independent and significant predictors of overall survival were lymph node metastases (p = 0.04), extrahepatic lesions (p = 0.03), and a low CALLY index (p = 0.03). Patients with a low CALLY index had significantly more postoperative complications than those with a high CALLY index (29% vs. 11%, p < 0.01).
CONCLUSION
The CALLY index may be an independent and significant indicator of outcomes in patients who underwent liver resection for CRLM.
目的
C反应蛋白（CRP）-白蛋白-淋巴细胞（CALLY）指数是一种基于炎症的新型生物标志物。我们旨在研究CALLY指数能否预测结直肠癌肝转移（CRLM）患者肝切除术后的预后。
方法
我们纳入了183例行肝切除术的CRLM患者。CALLY指数定义为（白蛋白×淋巴细胞）/（CRP×10）。我们通过单因素和多因素分析研究CALLY指数与总生存期的相关性。
结果
共有101例（55%）患者CALLY指数较低（<4）。在单因素分析中，有淋巴结转移（p = 0.02）、肝外病变（p < 0.01）和CALLY指数较低（p < 0.01）的患者总生存期明显较差。在多因素分析中，总生存期的独立且显著预测因素为淋巴结转移（p = 0.04）、肝外病变（p = 0.03）和CALLY指数较低（p = 0.03）。CALLY指数较低的患者术后并发症明显多于CALLY指数较高的患者（29%对11%，p < 0.01）。
结论
CALLY指数可能是CRLM肝切除患者预后的一个独立且重要的指标。
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