基于纳米技术的眼药水：眼部疾病的局部和非侵入性治疗。
Nano-based eye drop: Topical and noninvasive therapy for ocular diseases.
机构信息
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
出版信息
Adv Drug Deliv Rev. 2023 Mar;194:114721. doi: 10.1016/j.addr.2023.114721. Epub 2023 Feb 10.
Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering from their lower bioavailability which highly restricts the treatment efficacy. The introduction of nanotechnology has attracted considerable interest as it has advantages over conventional ones such as prolonged ocular surface retention time and enhanced ocular barrier penetrating properties, and achieving higher bioavailability and improved treatment efficacy. This review describes various ocular diseases treated with eye drops as well as the physiological and anatomical ocular barriers faced with through drug administration. It also summarizes the recent advances regarding the utilization of nanotechnology in developing eye drops, and how to optimize the nanocarrier-based ocular drug delivery systems. The prospective future research directions for nano-based eye drops are also discussed here.
眼药水是治疗眼部疾病最便捷的方法，但不可避免地存在生物利用度较低的问题，这极大地限制了治疗效果。引入纳米技术引起了广泛关注，因为它具有优于传统技术的优势，例如延长眼表滞留时间和增强眼屏障穿透特性，从而实现更高的生物利用度和改善治疗效果。本综述描述了各种眼部疾病的眼药水治疗方法，以及药物给药时面临的生理和解剖学眼部屏障。它还总结了最近在利用纳米技术开发眼药水方面的进展，以及如何优化基于纳米载体的眼部药物传递系统。此外，还讨论了基于纳米技术的眼药水的未来研究方向。
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