Division of Pulmonary and Critical Care Medicine, University of Virginia School of Medicine, PO Box 800546, Clinical Department Wing, 1 Hospital Drive, Charlottesville, VA 22908, USA.
Division of Respirology, Department of Medicine, University Health Network and University of Toronto, C. David Naylor Building, 6 Queen's Park Crescent West, Third Floor, Toronto, ON M5S 3H2, Canada.
Clin Chest Med. 2023 Mar;44(1):15-33. doi: 10.1016/j.ccm.2022.10.001.
Lung transplantation can be lifesaving for patients with advanced lung disease. Demographics are evolving with recipients now sicker but determining candidacy remains predicated on one's underlying lung disease prognosis, along with the likelihood of posttransplant success. Determining optimal timing can be challenging, and most programs favor initiating the process early and proactively to allow time for patient education, informed decision-making, and preparation. A comprehensive, multidisciplinary evaluation is used to elucidate disease progrnosis and identify risk factors for poor posttransplant outcomes. Candidacy criteria vary significantly by center, and close communication between referring and transplant providers is necessary to improve access to transplant and outcomes.
肺移植可为晚期肺部疾病患者提供救命机会。受者的人口统计学特征正在发生变化，现在他们的病情更加严重，但确定候选资格仍然取决于患者的基础肺部疾病预后，以及移植后成功的可能性。确定最佳时机可能具有挑战性，大多数方案都倾向于尽早积极地启动该过程，以便为患者提供教育、知情决策和准备的时间。综合的多学科评估用于阐明疾病预后，并确定移植后不良结局的风险因素。候选标准因中心而异，因此转诊和移植提供者之间需要密切沟通，以改善移植机会和结果。
