HEGITO (Div Hepatology, Gastroenterology and Liver Transplant), 2nd Department of Internal Medicine, Faculty of Medicine, Slovak Medical University, F. D. Roosevelt Teaching Hospital, Banská Bystrica, Slovakia.
2nd Department of Internal Medicine, Faculty of Medicine, P. J. Safarik University, Kosice, Slovakia.
Sci Rep. 2023 Feb 11;13(1):2463. doi: 10.1038/s41598-023-29510-2.
Liver cirrhosis is associated with a poor quality of life (QOL). The COVID-19 pandemic has led to several restriction measures and psychosocial consequences whose impact on QOL has combined with that of cirrhosis in an unknown way. Therefore, we have used our cirrhosis registry to assess the quality of life before the pandemic (on the first admission to the tertiary liver unit) and during the most pronounced phase of the first lockdown. In this cross-sectional study conducted during the first lockdown in Slovakia (from April to May 2020), we have repeated the QOL measurement of QOL in cirrhotic patients previously enrolled in the RH7 registry. Patients who were alive (according to the national registry of deaths) were identified and contacted by phone with a structured and standardized interview led by trained professionals. The tool used for both QOL measurements (at enrolment in RH7 and during lockdown) was a standardized and validated EuroQOL-5D (EQ-5D) questionnaire. The study included 97 patients, of which 37 (38.1%) were women and 60 (61.9%) were men. Responses were achieved from 75 patients (68.18%). In general, patients scored their quality of life significantly higher during the pandemic compared to examination at admission to RH7 (that is, at admission to our tertiary liver unit with cirrhosis) (p = 0.005). In particular, of the domains included in EQ-5D: (1) self-care was better during lockdown compared to the first record on admission to RH7 (p < 0.001). (2) the ability to perform daily activities has also improved during lockdown (p = 0.002). On the other hand, (3) pain and discomfort did not change significantly during the lockdown compared to the previous measurement (p = 0.882). (4) anxiety and depression were lower during lockdown compared to admission to RH7 (p = 0.01). The quality of life in patients with liver cirrhosis was better during the lockdown of SARS-CoV-2 compared to the previous measurement at admission to the tertiary liver unit.
肝硬化与生活质量（QOL）较差有关。COVID-19 大流行导致了多项限制措施和心理社会后果，其对 QOL 的影响与肝硬化以未知的方式结合在一起。因此，我们使用肝硬化登记处来评估大流行前（在三级肝脏单位首次入院时）和第一次封锁最明显阶段的生活质量。在斯洛伐克第一次封锁期间进行的这项横断面研究中（2020 年 4 月至 5 月），我们对先前登记在 RH7 登记处的肝硬化患者的生活质量进行了重复测量。根据国家死亡登记册，确定了仍在世的患者，并通过电话与经过培训的专业人员进行结构化和标准化的访谈进行联系。两次 QOL 测量（在 RH7 登记时和封锁期间）使用的工具是标准化和验证的 EuroQOL-5D（EQ-5D）问卷。该研究包括 97 名患者，其中 37 名（38.1％）为女性，60 名（61.9％）为男性。从 75 名患者（68.18％）中获得了回复。总体而言，与 RH7 入院时的检查相比（即，在我们的三级肝脏单位因肝硬化入院时），患者在大流行期间的生活质量评分明显更高（p=0.005）。特别是，在包括在 EQ-5D 中的领域中：（1）在封锁期间，自我护理要好于 RH7 第一次记录时（p<0.001）。（2）在封锁期间，进行日常活动的能力也有所提高（p=0.002）。另一方面，（3）在封锁期间，疼痛和不适没有与前一次测量相比发生重大变化（p=0.882）。（4）在封锁期间，焦虑和抑郁程度低于 RH7 入院时（p=0.01）。与第三次肝脏单位入院时的前一次测量相比，肝硬化患者在 SARS-CoV-2 封锁期间的生活质量更好。
