Suppr超能文献

挪威涉及撞车事故且四氢大麻酚检测呈阳性的司机存在多种物质使用的高频率情况。

Crash-involved THC-positive drivers in Norway have a high frequency of polysubstance use.

作者信息

Gjerde Hallvard, Bogstrand Stig Tore, Jamt Ragnhild Elén Gjulem, Vindenes Vigdis

机构信息

Section of Drug Abuse Research, Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway.

Section of Drug Abuse Research, Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway; Department of Public Health Science, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Nursing and Health Promotion, Acute and Critical Illness, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.

出版信息

Drug Alcohol Depend. 2023 Mar 1;244:109800. doi: 10.1016/j.drugalcdep.2023.109800. Epub 2023 Feb 8.

Abstract

BACKGROUND

Tetrahydrocannabinol (THC) is the most frequently detected drug in blood samples from apprehended drug driving suspects in Norway. This investigation aimed to study the extent of polysubstance use among apprehended crash-involved drivers with THC concentrations above the legal limit and explore the importance of THC in polysubstance cases.

METHODS

We selected all drug driving cases where blood samples had been submitted for forensic toxicology testing after involvement in road traffic crashes during 2013-2020, except drivers who were fatally injured.

RESULTS

Twenty percent (n = 2133) of the 10,520 apprehended crash-involved drivers had concentrations of THC in their blood above the legal limit of 1.3 ng/mL, and 84 % of those also had concentrations of alcohol or other drugs above the legal limits; 61 % for sedatives, 38 % for stimulants, 33 % for alcohol, and 10 % for opioids. The most frequent substance combination was cannabis together with sedatives and stimulants (22.9 %; n = 488). Polysubstance use was least common among drivers under 24 years. The proportion of drivers with THC > 5 ng/mL was highest if the blood sample was collected within 90 min after the crash, and when only THC was detected. There was a statistically significant inverse association between THC > 5 ng/mL and concentrations of alcohol or amphetamines at the highest sanction level.

CONCLUSIONS

Most apprehended crash-involved THC-positive drivers also tested positive for other psychoactive substances. Drivers with high blood THC concentrations had less often high concentrations of other substances; cannabis might then have been a more important contributor to impairment.

摘要

背景

四氢大麻酚(THC)是挪威被逮捕的涉嫌药物驾驶嫌疑人血液样本中最常检测到的药物。本研究旨在调查血液中THC浓度超过法定限值的涉交通事故被捕司机中多物质使用的程度,并探讨THC在多物质案件中的重要性。

方法

我们选取了2013年至2020年期间所有涉交通事故后提交血液样本进行法医毒理学检测的药物驾驶案件,但不包括受致命伤的司机。

结果

在10520名涉交通事故被捕司机中,20%(n = 2133)血液中的THC浓度超过法定限值1.3 ng/mL,其中84%的人血液中酒精或其他药物浓度也超过法定限值;镇静剂为61%,兴奋剂为38%,酒精为33%,阿片类药物为10%。最常见的物质组合是大麻与镇静剂和兴奋剂(22.9%;n = 488)。多物质使用在24岁以下的司机中最不常见。如果在事故发生后90分钟内采集血液样本且仅检测到THC,则THC>5 ng/mL的司机比例最高。在最高处罚级别,THC>5 ng/mL与酒精或苯丙胺浓度之间存在统计学上显著的负相关。

结论

大多数涉交通事故被捕的THC阳性司机其他精神活性物质检测也呈阳性。血液中THC浓度高的司机其他物质浓度高的情况较少;因此大麻可能是导致驾驶能力受损的更重要因素。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验