呼气末一氧化碳浓度的时间进程在吸烟研究中很重要。

Time course of end-expired carbon monoxide concentration is important in studies of cigarette smoking.

Woodman G, Wintoniuk D M, Taylor R G, Clarke S W

Department of Thoracic Medicine, Royal Free Hospital, London.

Clin Sci (Lond). 1987 Nov;73(5):553-5. doi: 10.1042/cs0730553.

Abstract

Fifteen asymptomatic habitual smokers each smoked one of their usual cigarettes, not having smoked for 2 h. End-expired carbon monoxide concentration (EECO) was measured with an Ecolyzer 2000 series analyser before smoking (pre-S value), 1 min after finishing smoking (post-S value) and then at intervals up to 1 h. 2. The mean EECO boost (increase) over all subjects declined biphasically after smoking, with an initial fast phase from 1 to 5 min, and then a slow phase from 5 to 60 min. EECO fell by as much in the first 5 min as in the next hour. 3. Post-S EECO was related to pre-S EECO (r = 0.89, P less than 0.001), but EECO boost was not related to pre-S (r = 0.00). EECO boost was unaffected by the sampling manoeuvre. 4. EECO measurements in epidemiological and smoking studies should not be made for at least 5 min after a cigarette is finished.

摘要

15名无症状习惯性吸烟者每人吸一支他们平常吸的香烟，且在吸烟前2小时未吸烟。在吸烟前（吸烟前值）、吸完烟1分钟后（吸烟后值），然后每隔一定时间直至1小时，用Ecolyzer 2000系列分析仪测量终末呼气一氧化碳浓度（EECO）。2. 所有受试者吸烟后EECO的平均升高呈双相下降，最初是1至5分钟的快速期，然后是5至60分钟的缓慢期。EECO在前5分钟下降的幅度与接下来1小时下降的幅度相同。3. 吸烟后EECO与吸烟前EECO相关（r = 0.89，P小于0.001），但EECO升高与吸烟前EECO无关（r = 0.00）。EECO升高不受采样操作的影响。4. 在流行病学和吸烟研究中，香烟吸完后至少5分钟内不应进行EECO测量。