Fisher B, Rodarte A
Department of Anesthesia/Critical Care, Children's Hospital, San Diego, CA 92123.
Crit Care Med. 1987 Nov;15(11):1072-3. doi: 10.1097/00003246-198711000-00019.
We treated a brain-damaged 8-month-old male with iv doxapram in order to discontinue mechanical ventilation. We were able to monitor intracranial pressure (ICP) throughout the course of doxapram via an ICP monitor. Despite normal and then excessive PaCO2, the patient's spontaneous respiratory rate remained nil before doxapram treatment. However, after an iv bolus dose followed by a maintenance drip, the patient's spontaneous respiratory rate increased while his ICP remained at baseline or slightly less than baseline, thereby allowing mechanical ventilation to be discontinued.
我们对一名8个月大的脑损伤男性患者静脉注射多沙普仑，以停止机械通气。在使用多沙普仑的整个过程中，我们能够通过颅内压监测仪监测颅内压（ICP）。尽管动脉血二氧化碳分压（PaCO2）先是正常随后升高，但在多沙普仑治疗前患者的自主呼吸频率仍为零。然而，在静脉推注一剂后接着持续滴注，患者的自主呼吸频率增加，而其颅内压保持在基线水平或略低于基线水平，从而得以停止机械通气。
