Ranquin R
University Hospital, Antwerp, Belgium.
Curr Med Res Opin. 1987;10(8):521-6. doi: 10.1185/03007998709108960.
Twenty-two patients showing persistent endogenous hypertriglyceridaemia after an individually designed diet for 1 month were randomly divided into two groups. Each was treated during two crossover consecutive 40-day periods, either starting with benfluorex (450 mg/day) or with placebo. They were followed as out-patients and were investigated at the start of the study, and at the end of each treatment period. A number of laboratory measurements were undertaken at each visit, including triglycerides, cholesterol, uric acid, fatty acids, and glucose and insulin after an oral glucose tolerance test. The results showed a significant (p less than 0.01) reduction in triglyceride blood levels of 32.7% after benfluorex treatment compared to 11.7% with placebo, irrespective of the treatment order. Other laboratory measurements were in the normal range, and there were no significant changes, except for uric acid which showed a small decrease but of little clinical significance. Benfluorex would appear to have an important therapeutic effect on endogenous hypertriglyceridaemia.
22名患者在接受为期1个月的个性化饮食治疗后仍表现为持续性内源性高甘油三酯血症，他们被随机分为两组。每组在两个连续的40天交叉治疗期内接受治疗，一组从服用苄氟雷司（450毫克/天）开始，另一组从服用安慰剂开始。他们作为门诊患者接受随访，并在研究开始时以及每个治疗期结束时接受检查。每次就诊时都进行了多项实验室检测，包括甘油三酯、胆固醇、尿酸、脂肪酸，以及口服葡萄糖耐量试验后的血糖和胰岛素。结果显示，无论治疗顺序如何，苄氟雷司治疗后甘油三酯血水平显著降低（p<0.01），降低了32.7%，而安慰剂组仅降低了11.7%。其他实验室检测结果均在正常范围内，除尿酸略有下降但临床意义不大外，均无显著变化。苄氟雷司似乎对内源性高甘油三酯血症具有重要的治疗作用。
