Wagener J S, Hendricker C
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City.
Chest. 1987 Dec;92(6):1047-9. doi: 10.1378/chest.92.6.1047.
We studied ten healthy, nonsmoking adults to determine the intra-subject variability for repeated measurements of transcutaneous oxygen pressure (tcPO2) and oxygen saturation by pulse oximetry (SaO2). Intra-subject variability was less for SaO2 than for tcPO2 and increased at lower arterial oxygen tensions. Inter-machine variability was an important contributor to intra-subject variability for tcPO2. The percentage change from baseline required to detect a significant physiologic change while breathing room air was 1.2 percent for SaO2 and 13.8 percent for tcPO2. When subjects breathed a 15 percent oxygen mixture, the percentage change for significance increased to a maximum of 4.7 percent for SaO2 and 35.8 percent for tcPO2. These results are applicable to non-neonatal pediatric and adult patients and demonstrate the importance of intra-subject variability when performing noninvasive measurements of patient oxygenation over time.
我们研究了10名健康、不吸烟的成年人，以确定经皮氧分压（tcPO2）和脉搏血氧饱和度（SaO2）重复测量的受试者内变异性。SaO2的受试者内变异性低于tcPO2，且在较低动脉氧分压时增加。机器间变异性是tcPO2受试者内变异性的重要因素。在呼吸室内空气时，检测到显著生理变化所需的相对于基线的百分比变化，SaO2为1.2%，tcPO2为13.8%。当受试者呼吸15%的氧气混合物时，显著性的百分比变化增加，SaO2最高可达4.7%，tcPO2最高可达35.8%。这些结果适用于非新生儿儿科和成年患者，并证明了在对患者氧合进行长期无创测量时受试者内变异性的重要性。
